Department of Cardiovascular Surgery, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, Anhui, 230001, China.
BMC Psychiatry. 2023 Apr 17;23(1):259. doi: 10.1186/s12888-023-04770-4.
Remnant cholesterol is receiving increasing attention because of its association with various diseases. However, there have been no studies on remnant cholesterol levels and depression.
A cross-sectional analysis was performed based on the National Health and Nutrition Examination Survey (NHANES) 2005-2016. Depression was assessed using a Patient Health Questionnaire (PHQ-9). Fasting remnant cholesterol was calculated as the total cholesterol minus high-density lipoprotein cholesterol (HDL-C) minus low-density lipoprotein cholesterol (LDL-C). Logistic regression analysis with sampling weights was used to examine the association between remnant cholesterol concentration and depression.
Among 8,263 adults enrolled in this study (weighted mean age, 45.65 years), 5.88% (weighted percentage) had depression. Compared to the participants without depression, those with depression had higher concentration of remnant cholesterol (weighted mean, 26.13 vs. 23.05, P < 0.001). There was a significant positive relationship between remnant cholesterol concentration and depression and multivariable-adjusted OR with 95% CI was 1.49 (1.02-2.17). Among the subgroup analyses, remnant cholesterol concentration was positively associated with depression among participants less than 60 years (OR, 1.62; 95% CI, 1.09-2.42), male (OR, 2.02; 95% CI, 1.01-4.05), BMI under 30 (OR, 1.83; 95% CI, 1.14-2.96), and those with diabetes (OR, 3.88; 95% CI, 1.43-10.49).
Remnant cholesterol concentration positively correlated with depression, suggesting that a focus on remnant cholesterol may be useful in the study of depression.
由于与各种疾病有关，残胆固醇受到越来越多的关注。然而，目前还没有关于残胆固醇水平与抑郁症关系的研究。
基于 2005-2016 年国家健康和营养检查调查（NHANES）进行横断面分析。使用患者健康问卷（PHQ-9）评估抑郁症。空腹残胆固醇计算为总胆固醇减去高密度脂蛋白胆固醇（HDL-C）减去低密度脂蛋白胆固醇（LDL-C）。使用带抽样权重的逻辑回归分析来检验残胆固醇浓度与抑郁症之间的关系。
在这项研究中，纳入了 8263 名成年人（加权平均年龄为 45.65 岁），其中 5.88%（加权百分比）患有抑郁症。与没有抑郁症的参与者相比，有抑郁症的参与者残胆固醇浓度更高（加权平均值，26.13 与 23.05，P<0.001）。残胆固醇浓度与抑郁症之间存在显著正相关，调整后的多变量比值比（95%置信区间）为 1.49（1.02-2.17）。在亚组分析中，在年龄小于 60 岁的参与者（比值比，1.62；95%置信区间，1.09-2.42）、男性（比值比，2.02；95%置信区间，1.01-4.05）、BMI 低于 30（比值比，1.83；95%置信区间，1.14-2.96）和患有糖尿病的参与者（比值比，3.88；95%置信区间，1.43-10.49）中，残胆固醇浓度与抑郁症呈正相关。
残胆固醇浓度与抑郁症呈正相关，这表明关注残胆固醇可能有助于研究抑郁症。
