Labcorp Central Laboratory Services Limited Partnership, Bangalore, India.
National Forensic Sciences University, Gandhinagar, India.
Vascul Pharmacol. 2023 Apr;149:107144. doi: 10.1016/j.vph.2023.107144. Epub 2023 Feb 3.
Opioids are widely being used for chronic pain management, cough and diarrhea suppressants, anesthetic agents, and opioid de-addiction therapy. Opioid receptors, present in the central nervous system and peripheral tissues, are documented to regulate several cardiac functions through different signaling pathways. Long-acting opioids (LAO) have been successfully evaluated for their beneficial effects in various cardiovascular diseases viz. myocardial infarction, ischemic reperfusion injuries, atherosclerosis etc. However, on the other hand, several research studies pointed towards the harmful effects of LAOs which are mainly associated with QTc prolongation, torsade de pointes, ventricular arrhythmias, and cardiac arrest. This review shall familiarize readers with the benefits as well as the harmful effects of long-acting opioids in cardiovascular diseases. We have also provided an overview of cardiac opioid receptors, endogenous cardiac opioid peptides, and regulation of cardiovascular functions by central and cardiac opioid receptors.
阿片类药物被广泛用于慢性疼痛管理、咳嗽和腹泻抑制剂、麻醉剂以及阿片类药物戒除治疗。阿片受体存在于中枢神经系统和外周组织中，通过不同的信号通路来调节多种心脏功能，这已被记录在案。长效阿片类药物（LAO）已成功评估了其在多种心血管疾病中的有益作用，例如心肌梗死、缺血再灌注损伤、动脉粥样硬化等。然而，另一方面，几项研究指出 LAO 具有有害作用，主要与 QTc 延长、尖端扭转型室性心动过速、室性心律失常和心脏骤停有关。本综述将使读者熟悉长效阿片类药物在心血管疾病中的益处和有害作用。我们还概述了心脏阿片受体、内源性心脏阿片肽以及中枢和心脏阿片受体对心血管功能的调节。
