儿童白细胞介素-12 受体β1 缺陷症合并播散性耐多药结核分枝杆菌和严重急性呼吸综合征冠状病毒 2 感染
Disseminated multidrug-resistant tuberculosis and SARS-CoV-2 co-infection in a child with IL-12Rβ1 deficiency.
机构信息
Epilepsy Clinic, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.
Infectology, Maternal and Child Hospital Institute of Social Security of the State of Mexico and Municipalities (ISSSM&M), Tomas Alva Edison S/n, Delegación San Lorenzo Tepaltitlán I, Delegación San Lorenzo Tepaltitlán, 50160 Toluca de Lerdo, Mexico.
出版信息
Indian J Tuberc. 2023 Jan;70(1):129-133. doi: 10.1016/j.ijtb.2022.04.008. Epub 2022 Apr 30.
Mendelian Susceptibility to Mycobacterial Disease describes a spectrum of inherited defects, of which complete deficiency of the interleukin-12 receptor β subunit 1 (IL-12Rβ1) is the most common cause. This condition results in a predisposition to severe disease caused by mycobacteria. We report a case of disseminated multidrug-resistant tuberculosis with extensive central nervous system affection with SARS-CoV-2 co-infection, in a 4-year-old child with IL-12Rβ1 complete deficiency.
孟德尔易感性分枝杆菌病描述了一系列遗传性缺陷，其中白细胞介素-12 受体 β 亚基 1（IL-12Rβ1）完全缺失是最常见的原因。这种情况导致对由分枝杆菌引起的严重疾病的易感性。我们报告了一例伴有 SARS-CoV-2 合并感染的 IL-12Rβ1 完全缺失的 4 岁儿童的播散性耐多药结核伴广泛中枢神经系统受累的病例。
Zotero 插件