Diabetes Research Centre, University of Leicester, Leicester General Hospital, Gwendolen Road, Leicester, LE5 4WP, UK; National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital, Bristol, UK.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Nutr Metab Cardiovasc Dis. 2023 Apr;33(4):864-867. doi: 10.1016/j.numecd.2023.01.016. Epub 2023 Jan 24.
Circulating C-reactive protein (CRP) and albumin are commonly used inflammatory biomarkers. C-reactive protein-to-albumin ratio (CAR), a novel inflammatory biomarker, has been suggested to be a more reliable risk indicator compared to CRP or albumin alone. An inflammatory hypothesis has been postulated in VTE aetiology, but the association between CAR and VTE has not been investigated. We aimed to assess the prospective association of CAR with VTE risk.
C-reactive protein and albumin were measured in serum samples at baseline from 2479 men aged 42-61 years. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated. During a median follow-up of 27.0 years, 168 VTE cases were recorded. In analysis adjusted for potential confounders, the HR (95% CI) for VTE comparing extreme tertiles of CAR was 1.49 (1.01-2.21), which was minimally attenuated on further adjustment for prevalent cancer, a potential mediator 1.48 (1.00-2.19). Serum CRP and albumin were each modestly associated with VTE risk in the same set of participants.
In middle-aged and older men, elevated serum CAR may be associated with an increased risk of VTE. Further research is needed to replicate or refute these findings in other populations and assess if CAR may be of potential value in VTE management.
循环 C 反应蛋白（CRP）和白蛋白是常用的炎症生物标志物。C 反应蛋白与白蛋白比值（CAR）作为一种新型炎症生物标志物，与 CRP 或白蛋白单独使用相比，被认为是一种更可靠的风险指标。静脉血栓栓塞症（VTE）发病机制中提出了炎症假说，但 CAR 与 VTE 之间的关联尚未得到研究。我们旨在评估 CAR 与 VTE 风险的前瞻性关联。
在 2479 名年龄在 42-61 岁的男性的基线血清样本中测量 CRP 和白蛋白。估计了风险比（HR）及其 95%置信区间（CI）。在中位随访 27.0 年期间，记录了 168 例 VTE 病例。在调整潜在混杂因素的分析中，比较 CAR 极端三分位的 VTE 的 HR（95%CI）为 1.49（1.01-2.21），进一步调整潜在的中介物癌症患病率后，该值略有减弱，为 1.48（1.00-2.19）。在同一组参与者中，血清 CRP 和白蛋白与 VTE 风险均呈中度相关。
在中年和老年男性中，血清 CAR 升高可能与 VTE 风险增加相关。需要进一步的研究来在其他人群中复制或反驳这些发现，并评估 CAR 是否可能对 VTE 的管理有潜在价值。
