小胶质细胞在 AD 病理学中的作用。

Roles of Microglia in AD Pathology.

机构信息

Department of Physiology, Hengyang Medical School, University of South China, Hengyang, P.R. China.

Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, P.R. China.

出版信息

Curr Alzheimer Res. 2023;19(13):854-869. doi: 10.2174/1567205020666230203112351.

DOI:10.2174/1567205020666230203112351

PMID:36740796

Abstract

Amyloid plaques and neurofibrillary tangles are two main characteristics of Alzheimer's disease (AD). As cerebral resident phagocytes, microglia have different roles in Aβ pathology and tau pathology. In this review, we discuss microglial functions in the formation, clearance, and spread of Aβ and tau. Many receptors and enzymes, which are related to microglia, participate in AD pathologies and thus are thought to be potential targets of AD. So, making use of microglia can be beneficial to confine AD pathologies. To sum up, this article review the roles of microglia in AD pathology and possible corresponding treatments.

摘要

淀粉样斑块和神经纤维缠结是阿尔茨海默病（AD）的两个主要特征。作为脑内固有吞噬细胞，小胶质细胞在 Aβ 病理和 tau 病理中具有不同的作用。在这篇综述中，我们讨论了小胶质细胞在 Aβ 和 tau 的形成、清除和传播中的作用。许多与小胶质细胞相关的受体和酶参与 AD 病理，因此被认为是 AD 的潜在靶点。因此，利用小胶质细胞可以有助于限制 AD 病理。总之，本文综述了小胶质细胞在 AD 病理中的作用以及可能的相应治疗方法。