Chinese Materia Medica Pharmacology, Shandong Academy of Chinese Medicine, Jinan 250014, China.
Shandong VeriSign Test Detection Co., LTD, Jinan, China.
Curr Med Chem. 2024;31(1):7-24. doi: 10.2174/0929867330666230203124032.
Heparin, as a glycosaminoglycan, is known for its anticoagulant and antithrombotic properties for several decades. Heparin is a life-saving drug and is widely used for anticoagulation in medical practice. In recent years, there have been extensive studies that heparin plays an important role in non-anticoagulant diseases, such as anti-inflammatory, anti-viral, anti-angiogenesis, anti-neoplastic, anti-metastatic effects, and so on. Clinical observation and in vitro experiments indicate that heparin displays a potential multitarget effect. In this brief review, we will summarize heparin and its derivative's recently studied progress for the treatment of various viral infections. The aim is to maximize the benefits of drugs through medically targeted development, to meet the unmet clinical needs of serious viral diseases.
肝素作为一种糖胺聚糖，几十年来因其抗凝和抗血栓特性而闻名。肝素是一种救命药物，在医学实践中被广泛用于抗凝。近年来，有大量研究表明肝素在非抗凝疾病中发挥着重要作用，如抗炎、抗病毒、抗血管生成、抗肿瘤、抗转移等作用。临床观察和体外实验表明，肝素具有潜在的多靶点效应。在这篇简要综述中，我们将总结肝素及其衍生物在治疗各种病毒感染方面的最新研究进展。目的是通过有针对性的药物开发最大限度地发挥药物的效益，以满足严重病毒疾病的未满足的临床需求。
