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Notch3 和 DLL4 在人乳腺癌中的表达及预后价值。

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer.

机构信息

481873Shihezi University School of Medicine, Shihezi, Xinjiang, China.

Changle People's Hospital, Weifang, Shandong, China.

出版信息

Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338221118984. doi: 10.1177/15330338221118984.

DOI:10.1177/15330338221118984
PMID:36740988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9903027/
Abstract

: Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored. The retrospective study enrolled 90 breast cancer tissues and 60 noncancerous tissues from (conceal). The expression and prognostic value of Notch3 and DLL4 in patients with breast carcinoma were investigated using Oncomine and UALCAN database. Notch3 and DLL4 expression levels were detected by quantitative real-time polymerase chain reaction, western blotting, and immunohistochemistry. We analyzed the correlation between both proteins expression and clinicopathological parameters and survival data, respectively. The expressions of Notch3 and DLL4 were increased, and Notch3 expression was significantly positively associated with DLL4 in breast carcinoma. The 2 proteins dramatically correlated with advanced stage, high grade and negative Her2 status. The overexpressing of single or both Notch3 and DLL4 resulted in shortened survival of breast cancer patients. And Notch3 overexpression was one of independent risk predictors to poor prognosis. The interaction of Notch3 receptor and DLL4 ligand accelerates oncogenesis, progression, and poor prognosis of breast cancer patients. Notch3 protein may serve as one of biomarker to independently predict prognosis of patients.

摘要

: Notch 信号通路在促进乳腺癌的发生和发展中起着关键作用。然而，Notch3 与 DLL4 表达的联合作用及其在乳腺癌中的预后价值尚未得到探索。本回顾性研究纳入了 90 例乳腺癌组织和 60 例非癌组织（隐匿）。通过 Oncomine 和 UALCAN 数据库研究 Notch3 和 DLL4 在乳腺癌患者中的表达及其预后价值。通过实时定量聚合酶链反应、western blot 和免疫组织化学检测 Notch3 和 DLL4 的表达水平。我们分别分析了这两种蛋白表达与临床病理参数和生存数据之间的相关性。Notch3 和 DLL4 的表达增加，并且 Notch3 的表达与乳腺癌中的 DLL4 呈显著正相关。这两种蛋白与晚期、高级别和 Her2 阴性状态显著相关。Notch3 和 DLL4 的单一或联合过表达导致乳腺癌患者的生存时间缩短。Notch3 过表达是预后不良的独立危险因素之一。Notch3 受体与 DLL4 配体的相互作用加速了乳腺癌患者的癌变、进展和不良预后。Notch3 蛋白可能作为独立预测患者预后的生物标志物之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/f17ee2a42c81/10.1177_15330338221118984-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/76b5488050a5/10.1177_15330338221118984-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/dd54ae246f11/10.1177_15330338221118984-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/e26e9bea4118/10.1177_15330338221118984-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/11d7e88a6d4f/10.1177_15330338221118984-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/21d8b9a1201b/10.1177_15330338221118984-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/f17ee2a42c81/10.1177_15330338221118984-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/76b5488050a5/10.1177_15330338221118984-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/dd54ae246f11/10.1177_15330338221118984-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/e26e9bea4118/10.1177_15330338221118984-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/11d7e88a6d4f/10.1177_15330338221118984-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/21d8b9a1201b/10.1177_15330338221118984-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9100/9903027/f17ee2a42c81/10.1177_15330338221118984-fig6.jpg

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