Ghazwani Yahya, Sabbah Belal N, Algahfees Mohammad A, Arabi Tarek Z, Alageel Abdulrahman K, Musalli Ziyad F, Almutairi Ebtesam S, Alasker Ahmed
College of Medicine, King Saud University.
Department of Urology, King Abdulaziz Medical City.
Ann Med Surg (Lond). 2023 Jan 18;85(1):13-16. doi: 10.1097/MS9.0000000000000123. eCollection 2023 Jan.
Prostate cancer is the third leading cause of death from cancer among American men. Acinar adenocarcinoma is the most common form of prostate cancer; however, there are several nonacinar adenocarcinoma variants, such as transitional cell carcinoma of the prostate and ductal adenocarcinoma.
A retrospective cohort study was conducted on all Saudi patients diagnosed with adenocarcinoma of the prostate with transitional cell features. The data was collected from the Saudi Cancer Registry, which collects tumor data from all private, military, and Health Ministry hospitals in Saudi Arabia through five regional offices.
Out of 3608 patients, only 16 (0.44%) had adenocarcinoma with transitional cell features. All the tumors under investigation were malignant and constituted. Only 6.2% of the tumors were well-differentiated, 43.8% were moderately differentiated, and 50.0% were poorly differentiated. Among the included patients, 56.3% of the patients (=9) died. There were no significant factors associated with death among patients, including the demographic and tumor-related variables.
To the authors' knowledge, this is the first study describing the prevalence of adenocarcinoma with transitional cell features and its characteristics in Saudi Arabia. The authors have demonstrated that this rare subtype may be more prevalent than what was originally believed. It is necessary for future studies to assess the effectiveness of various treatment modalities to combat it. Furthermore, identifying risk factors - if any - may be crucial in the prevention of its development among men worldwide.
前列腺癌是美国男性癌症死亡的第三大主要原因。腺泡腺癌是前列腺癌最常见的形式；然而，也存在几种非腺泡腺癌变体，如前列腺移行细胞癌和导管腺癌。
对所有被诊断为具有移行细胞特征的前列腺腺癌的沙特患者进行了一项回顾性队列研究。数据来自沙特癌症登记处，该登记处通过五个地区办事处收集沙特阿拉伯所有私立、军事和卫生部医院的肿瘤数据。
在3608名患者中，只有16名（0.44%）患有具有移行细胞特征的腺癌。所有研究中的肿瘤均为恶性。只有6.2%的肿瘤为高分化，43.8%为中分化，50.0%为低分化。在所纳入的患者中，56.3%的患者（=9名）死亡。患者中没有与死亡相关的显著因素，包括人口统计学和肿瘤相关变量。
据作者所知，这是第一项描述沙特阿拉伯具有移行细胞特征的腺癌患病率及其特征的研究。作者已经证明，这种罕见的亚型可能比最初认为的更为普遍。未来的研究有必要评估各种治疗方式对抗它的有效性。此外，识别风险因素（如果有的话）对于在全球男性中预防其发生可能至关重要。
