Department of Emergency, Anestesiology and Medicine Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Curr Med Chem. 2023;30(39):4466-4478. doi: 10.2174/0929867330666230206095923.
Coronavirus-19 disease (COVID-19) is an infection with high morbidity and mortality. Obesity and low body mass index (BMI) have both been linked to severe COVID-19, but recent studies have failed to confirm these associations.
The aim of this study was to examine the relationship between BMI and disease progression in hospitalised patients with COVID-19.
We performed a monocentric, retrospective observational study at the Fondazione Policlinico Gemelli in Rome. We enrolled 1544 (977 men) patients who presented to the emergency department with a positive COVID-19 test between January and December 2021. We divided patients into five classes based on BMI. Demographic, clinical, laboratory, and radiological data were collected for all patients.
Of the 1544 patients, 1297 recovered after hospitalization, whereas 247 (16%) died. Of those who died, 16/247 (6.5%) had a BMI below18.5 kg/m, 72/247 (29%) had a BMI between 18.5 and 24.99 kg/m, 103/247 (42%) had a BMI between 25 and 29.99 kg/m, 36/247 (15%) had a BMI between 30 and 35 kg/m, and 20/247 (8%) had a BMI above 35 kg/m. After adjusting the results for age, sex, and concomitant diseases using multivariate logistic regression, we found a significantly increased risk of intensive care unit (ICU) admission in severely obese patients (BMI > 35) compared to normal weight patients (BMI: 18.5-24.99) (p > 0.001). Mortality was not associated with BMI.
We confirm that severe obesity is a risk factor for ICU admission in patients with COVID-19. No association was found between BMI and mortality.
冠状病毒病（COVID-19）是一种具有高发病率和死亡率的感染。肥胖症和低体重指数（BMI）都与严重的 COVID-19 有关，但最近的研究未能证实这些关联。
本研究旨在检查 BMI 与住院 COVID-19 患者疾病进展的关系。
我们在罗马的 Fondazione Policlinico Gemelli 进行了一项单中心、回顾性观察研究。我们招募了 1544 名（977 名男性）在 2021 年 1 月至 12 月期间因 COVID-19 检测呈阳性而到急诊就诊的患者。我们根据 BMI 将患者分为五组。收集了所有患者的人口统计学、临床、实验室和影像学数据。
在 1544 名患者中，1297 名在住院后康复，而 247 名（16%）死亡。在死亡患者中，16/247（6.5%）的 BMI 低于 18.5kg/m，72/247（29%）的 BMI 在 18.5 至 24.99kg/m 之间，103/247（42%）的 BMI 在 25 至 29.99kg/m 之间，36/247（15%）的 BMI 在 30 至 35kg/m 之间，20/247（8%）的 BMI 高于 35kg/m。使用多变量逻辑回归调整年龄、性别和合并症的结果后，我们发现与正常体重患者（BMI：18.5-24.99）相比，重度肥胖患者（BMI>35）入住重症监护病房（ICU）的风险显著增加（p>0.001）。BMI 与死亡率无关。
我们证实，严重肥胖是 COVID-19 患者入住 ICU 的危险因素。BMI 与死亡率之间没有关联。
