Christoper Andreas, Herman Herry, Abdulah Rizky, Zulhendri Felix, Sanjaya Ardo, Lesmana Ronny
Basic Biomedical Sciences Master Program, PMDSU Program Batch VI, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Department of Orthopaedics, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Curr Aging Sci. 2023;16(2):112-124. doi: 10.2174/1874609816666230206144212.
Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain affected by dementia processes.
This systematic review aims to elaborate on the involvement of the Hippo signaling pathway and autophagy in modulating the progression and severity of dementia in aging.
Searches were conducted on MEDLINE, Google Scholar, Scopus, and Web of Science databases.
The Hippo signaling pathway is dependent upon the transcriptional co-activator YAP/TAZ, which forms complexes with TEAD in the nucleus in order to maintain cell homeostasis. When the expression YAP/TAZ is reduced, transcriptional repression-induced atypical cell death, ballooning cell death, and necrosis will consequently occur in the neurons. Moreover, the autophagic proteins, such as LC3, ATG proteins, and Beclin, are reduced, resulting in the disruption of autophagosome formation and accumulation and the spread of misfolded proteins in the brain suffering from dementia.
The impairment of the Hippo signaling pathway and autophagy in the dementia process in aging should be considered since it might predict the severity, treatment, and prevention of dementia.
痴呆是一种与大脑衰老相关的神经认知障碍，主要影响海马体和大脑皮层。已发现河马信号通路和自噬蛋白在受痴呆症影响的大脑中受到干扰。
本系统评价旨在阐述河马信号通路和自噬在调节衰老过程中痴呆症的进展和严重程度方面的作用。
在MEDLINE、谷歌学术、Scopus和科学网数据库中进行检索。
河马信号通路依赖于转录共激活因子YAP/TAZ，YAP/TAZ在细胞核中与TEAD形成复合物以维持细胞内稳态。当YAP/TAZ的表达降低时，转录抑制诱导的非典型细胞死亡、气球样细胞死亡和坏死将在神经元中发生。此外，自噬蛋白，如LC3、自噬相关蛋白和贝克林蛋白减少，导致自噬体形成和积累的破坏以及错误折叠蛋白在患痴呆症的大脑中的扩散。
应考虑衰老过程中痴呆症进程中河马信号通路和自噬的损伤，因为它可能预测痴呆症的严重程度、治疗和预防。
