Yousif Jenna, Babalola Folawiyo, Campbell Caroline, Gottlieb Alice, Vargas Jessica, Mitchell Krystal
J Drugs Dermatol. 2023 Feb 1;22(2):223-225. doi: 10.36849/JDD.7067.
Copy: Palmoplantar psoriasis is a chronic, difficult-to-treat localized variant of psoriasis that affects the palms and soles, significantly affecting patient's quality of life.
To evaluate the synergistic effect of a fixed-combination topical lotion composed of halobetasol propionate 0.01% and tazarotene 0.045% in the treatment of palmoplantar psoriasis.
This was an open-label investigator-initiated trial involving 21 patients with moderate-to-severe palmoplantar plaque-type psoriasis who underwent treatment with halobetasol propionate 0.01% and tazarotene 0.045%. Subjects were assessed for disease severity using the palmoplantar Physician Global Assessment and the mean difference over time was compared using the Wilcoxon signed-rank test.
5 patients (24%) achieved a palmoplantar Physician Global Assessment of 0 or 1 after week 24 or last observation carried forward. The mean palmoplantar Physician Global Assessment significantly decreased from baseline (3.57) to week 24/last observation carried forward (2.38) (P<0.001).
Halobetasol propionate 0.01% and tazarotene 0.045% lotion demonstrated efficacy in adult patients with moderate-to-severe palmoplantar plaque-type psoriasis through significant improvement in palmoplantar Physician Global Assessment. The complementary mechanisms of action of the corticosteroid and tazarotene may be of benefit compared to monotherapeutic agents. J Drugs Dermatol. 2023;22(2): 223-225. doi:10.36849/JDD.7067.
复制：掌跖银屑病是银屑病的一种慢性、难以治疗的局限性变体，会影响手掌和脚底，严重影响患者的生活质量。
评估由0.01%丙酸氯倍他索和0.045%他扎罗汀组成的固定复方外用洗剂治疗掌跖银屑病的协同作用。
这是一项开放标签、由研究者发起的试验，纳入21例中度至重度掌跖斑块型银屑病患者，接受0.01%丙酸氯倍他索和0.045%他扎罗汀治疗。使用掌跖医师整体评估法评估疾病严重程度，并使用Wilcoxon符号秩检验比较随时间的平均差异。
5例患者（24%）在第24周或末次观察时实现掌跖医师整体评估为0或1。掌跖医师整体评估的平均值从基线时的（3.57）显著降至第24周/末次观察时的（2.38）（P<0.001）。
0.01%丙酸氯倍他索和0.045%他扎罗汀洗剂在中度至重度掌跖斑块型银屑病成年患者中显示出疗效，掌跖医师整体评估有显著改善。与单一治疗药物相比，皮质类固醇和他扎罗汀的互补作用机制可能有益。《药物皮肤病学杂志》。2023年；22(2): 223 - 225。doi:10.36849/JDD.7067。
