Arshinoff Steve A, Shi Runjie B
From the York Finch Eye Associates, Toronto, Ontario, Canada (Arshinoff); Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada (Arshinoff); Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada (Shi); Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (Shi).
J Cataract Refract Surg. 2023 May 1;49(5):538-542. doi: 10.1097/j.jcrs.0000000000001151.
To determine the amount of moxifloxacin remaining in the anterior chamber (AC), immediately after its injection using 3 current injection methods, assuming mixing and fluid exchange with the AC contents during injection of the drug, and to determine the most desirable injection method.
Department of Ophthalmology and Vision Sciences and Institute of Biomedical Engineering, University of Toronto, Toronto, Canada.
Mathematical modeling.
Mathematical modeling using first-order mixing methods were used to assess mixing.
The Kaiser method of injecting 0.5 mL × 100 μg/0.1 mL does not achieve the desired 500 μg level of moxifloxacin in the AC. The "straight from the bottle" method of injecting 0.1 mL × 500 μg/0.1 mL is fraught with potential error, yielding a relatively unreliable final amount in the AC. Injecting 0.5 to 0.6 mL × 150 μg/0.1 mL yields a result closest to the desired goal.
Based on the calculation, the most accurate of current methods to deliver 500 μg moxifloxacin intracamerally is the method of 150 μg/0.1 mL × 0.5 to 0.6 mL.
假设在注射药物期间与前房（AC）内容物发生混合和液体交换，使用3种当前的注射方法，确定注射莫西沙星后立即在前房（AC）中残留的莫西沙星量，并确定最理想的注射方法。
加拿大多伦多大学眼科与视觉科学系及生物医学工程研究所。
数学建模。
使用一阶混合方法进行数学建模以评估混合情况。
采用凯泽方法注射0.5 mL×100μg/0.1 mL不能在前房中达到所需的500μg莫西沙星水平。采用“直接从瓶中抽取”方法注射0.1 mL×500μg/0.1 mL存在潜在误差，在前房中产生的最终量相对不可靠。注射0.5至0.6 mL×150μg/0.1 mL产生的结果最接近预期目标。
基于计算，目前在前房内注入500μg莫西沙星最准确的方法是150μg/0.1 mL×0.5至0.6 mL的方法。
