Liu Huipan, Yang Xiao, You Zhouxiang, Hu Zhi, Chen Yue
Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Nuklearmedizin. 2023 Feb;62(1):38-44. doi: 10.1055/a-1984-8044. Epub 2023 Feb 6.
To investigate the clinical value of 68Ga-FAPI-04 PET/CT for initial staging of esophageal cancer.
A total of 44 newly diagnosed patients with esophageal cancer were included in the analysis on the basis of postoperative pathology or clinical and radiologic follow-up.
All primary lesions showed increased 68Ga-FAPI-04 uptake, with an SUVmax of 14.92 ± 6.91. A total of 561 lymph nodes were verified by surgery (507) or clinical and radiologic follow-up (54), of which 92 lymph nodes were diagnosed as showing metastases. Seventy-five lymph nodes with metastases showed positive findings on 68Ga-FAPI-04, with a diameter of about 1.06 ± 0.53 cm and SUVmax of 8.10±4.71. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for lymph node metastasis detection were 81.5%, 99.3%, 96.6%, 96.2%, and 96.5%, respectively.
68Ga-FAPI-04 PET/CT showed good diagnostic performance in detecting lymph node metastases of esophageal cancer.
探讨68Ga-FAPI-04 PET/CT在食管癌初始分期中的临床价值。
基于术后病理或临床及影像学随访，共纳入44例新诊断的食管癌患者进行分析。
所有原发灶均表现为68Ga-FAPI-04摄取增加，SUVmax为14.92±6.91。经手术（507个）或临床及影像学随访（54个）共证实561个淋巴结，其中92个淋巴结被诊断为有转移。75个有转移的淋巴结在68Ga-FAPI-04检查中表现为阳性，直径约为1.06±0.53 cm，SUVmax为8.10±4.71。检测淋巴结转移的灵敏度、特异度、准确度、阳性预测值和阴性预测值分别为81.5%、99.3%、96.6%、96.2%和96.5%。
68Ga-FAPI-04 PET/CT在检测食管癌淋巴结转移方面显示出良好的诊断性能。
