Graduate Course in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil.
Graduate Course in Pharmaceutical Sciences, Federal University of São Paulo, São Paulo, Brazil.
BMJ Open. 2023 Feb 6;13(2):e070332. doi: 10.1136/bmjopen-2022-070332.
The production of clinical practice guidelines (CPGs) has grown in the past years. Notwithstanding, the quality of these documents and their recommendations for the treatment of schizophrenia in children and adolescents is still unknown.
To assess the quality of the guidelines and recommendations for the treatment of schizophrenia in this population.
CPGs from 2004 to December 2020 were identified through a systematic search on EMBASE, MEDLINE, PsycINFO, PubMed, Epistemonikos, VHL, Global Index Medicus and specific CPG databases. The CPGs' quality was independently assessed by three reviewers using AGREE II and they were considered of high quality if they scored ≥60% in domains 3 and 6. The evidence classification systems were described, the quality of recommendations was assessed in pairs using AGREE-REX and the recommendations were compared.
The database search retrieved 3182 results; 2030 were screened and 29 were selected for full-text reading. Four guidelines were selected for extraction. Two CPGs were considered of high quality in the AGREE II assessment. We described the commonly agreed recommendations for each treatment phase. The pharmacological recommendations were described in all treatment phases. Scores of AGREE-REX were lower for psychosocial recommendations.
There are still few clinical studies and CPGs regarding schizophrenia in children and adolescents. The quality of the documents was overall low, and the quality of the recommendations report has much to improve. There is also a lack of transparency about the quality of the evidence and the strength of the recommendations.
CRD42020164899.
近年来，临床实践指南（CPG）的制作数量有所增加。尽管如此，这些文件的质量及其针对儿童和青少年精神分裂症治疗的建议的质量仍然未知。
评估针对该人群精神分裂症治疗的指南和建议的质量。
通过对 EMBASE、MEDLINE、PsycINFO、PubMed、Epistemonikos、VHL、全球索引医学和特定 CPG 数据库进行系统搜索，确定了 2004 年至 2020 年 12 月的 CPG。三位评审员独立评估 CPG 的质量，使用 AGREE II 进行评估，如果在第 3 域和第 6 域的得分≥60%，则认为 CPG 质量较高。描述了证据分类系统，使用 AGREE-REX 对推荐的质量进行了成对评估，并进行了比较。
数据库搜索共检索到 3182 项结果；筛选出 2030 项并进行了全文阅读，选择了 29 项进行全文阅读。选择了 4 项指南进行提取。在 AGREE II 评估中，有 2 项 CPG 被认为质量较高。我们描述了每个治疗阶段共同商定的建议。在所有治疗阶段都描述了药物治疗建议。心理社会建议的 AGREE-REX 评分较低。
针对儿童和青少年精神分裂症，仍然很少有临床研究和 CPG。文件的总体质量较低，建议报告的质量还有很大的改进空间。证据质量和建议强度的透明度也不足。
CRD42020164899。
