Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0317, Oslo, Norway.
Research Unit of Population Health, Faculty of Medicine, PO Box 5000, FI-90014 University of Oulu, Oulu, Finland.
BMC Med. 2023 Feb 6;21(1):43. doi: 10.1186/s12916-023-02742-9.
Numerous intrauterine factors may affect the offspring's growth during childhood. We aimed to explore if maternal and paternal prenatal lipid, apolipoprotein (apo)B and apoA1 levels are associated with offspring weight, length, and body mass index from 6 weeks to eight years of age. This has previously been studied to a limited extent.
This parental negative control study is based on the Norwegian Mother, Father and Child Cohort Study and uses data from the Medical Birth Registry of Norway. We included 713 mothers and fathers with or without self-reported hypercholesterolemia and their offspring. Seven parental metabolites were measured by nuclear magnetic resonance spectroscopy, and offspring weight and length were measured at 12 time points. Data were analyzed by linear spline mixed models, and the results are presented as the interaction between parental metabolite levels and offspring spline (age).
Higher maternal total cholesterol (TC) level was associated with a larger increase in offspring body weight up to 8 years of age (0.03 ≤ P ≤ 0.04). Paternal TC level was not associated with change in offspring body weight (0.17 ≤ P ≤ 0.25). Higher maternal high-density lipoprotein cholesterol (HDL-C) and apoA1 levels were associated with a lower increase in offspring body weight up to 8 years of age (0.001 ≤ P ≤ 0.005). Higher paternal HDL-C and apoA1 levels were associated with a lower increase in offspring body weight up to 5 years of age but a larger increase in offspring body weight from 5 to 8 years of age (0.01 ≤ P ≤ 0.03). Parental metabolites were not associated with change in offspring height or body mass index up to 8 years of age (0.07 ≤ P ≤ 0.99).
Maternal compared to paternal TC, HDL-C, and apoA1 levels were more strongly and consistently associated with offspring body weight during childhood, supporting a direct intrauterine effect.
许多宫内因素可能会影响儿童期后代的生长。我们旨在探讨母体和父体产前脂质、载脂蛋白（apo）B 和 apoA1 水平是否与后代从 6 周龄到 8 岁时的体重、身高和体重指数有关。此前对此进行了有限的研究。
这是一项基于挪威母亲、父亲和儿童队列研究的父母负对照研究，使用了挪威医学出生登记处的数据。我们纳入了 713 名有或没有自述高胆固醇血症的母亲和父亲及其后代。通过核磁共振波谱法测量了 7 种亲代代谢物，在 12 个时间点测量了后代的体重和身高。通过线性样条混合模型进行数据分析，结果以亲代代谢物水平与后代样条（年龄）之间的相互作用表示。
母体总胆固醇（TC）水平升高与后代体重增加有关，直到 8 岁时增加（0.03≤P≤0.04）。父体 TC 水平与后代体重变化无关（0.17≤P≤0.25）。母体高密度脂蛋白胆固醇（HDL-C）和 apoA1 水平升高与后代体重增加减少有关，直到 8 岁时（0.001≤P≤0.005）。父体 HDL-C 和 apoA1 水平升高与后代体重增加减少有关，直到 5 岁，但与 5 至 8 岁时后代体重增加增加有关（0.01≤P≤0.03）。亲代代谢物与 8 岁时后代身高或体重指数的变化无关（0.07≤P≤0.99）。
与父体相比，母体 TC、HDL-C 和 apoA1 水平与儿童期后代体重的关系更密切且更一致，支持宫内直接作用。
