Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
BMC Pregnancy Childbirth. 2022 Jul 23;22(1):588. doi: 10.1186/s12884-022-04905-7.
Maternal lipid levels in early pregnancy are associated with maternal health and foetal growth. It is however unclear if maternal lipids in early pregnancy can be used to predict childhood lipid levels. The aim of this study is to assess the association between maternal and offspring childhood lipid levels, and to investigate the influence of maternal BMI and diet on these associations.
This study included 2692 women participating in the Generation R study, an ongoing population-based prospective cohort study from early life onwards. Women with an expected delivery date between 2002 and 2006 living in Rotterdam, the Netherlands were included. Total cholesterol, triglycerides and high-density lipoprotein cholesterol (HDL-c) were measured in early pregnancy (median 13.2 weeks [90% range 10.6; 17.1]). Low-density lipoprotein cholesterol (LDL-c), remnant cholesterol and non-HDL-c were calculated. Corresponding lipid measurements were determined in 2692 children at the age of 6 (median 6.0 years [90% range 5.7; 7.5]) and 1673 children 10 years (median 9.7 years [90% range 9.5; 10.3]). Multivariate linear regression analysis was used to examine the association between maternal lipid levels in early pregnancy and the corresponding childhood lipid measurements at the ages of 6 and 10 years while adjusting for confounders.
Maternal lipid levels in early pregnancy are positively associated with corresponding childhood lipid levels 6 and 10 years after pregnancy, independent of maternal body mass index and diet.
Maternal lipid levels in early pregnancy may provide an insight to the lipid profile of children years later. Gestational lipid levels may therefore be used as an early predictor of children's long-term health. Monitoring of these gestational lipid levels may give a window-of-opportunity to start early interventions to decrease offspring's lipid levels and possibly diminish their cardiovascular risk later in life. Future studies are warranted to investigate the genetic contribution on maternal lipid levels in pregnancy and lipid levels of their offspring years later.
妊娠早期的母体脂质水平与母体健康和胎儿生长有关。然而，目前尚不清楚妊娠早期的母体脂质是否可用于预测儿童的脂质水平。本研究旨在评估母体和后代儿童脂质水平之间的关系，并研究母体 BMI 和饮食对这些关系的影响。
本研究纳入了 2692 名参加 Generation R 研究的女性，这是一项从生命早期开始的正在进行的基于人群的前瞻性队列研究。荷兰鹿特丹市的预期分娩日期在 2002 年至 2006 年之间的女性被纳入研究。在妊娠早期（中位数 13.2 周[90%范围 10.6；17.1]）测量总胆固醇、甘油三酯和高密度脂蛋白胆固醇（HDL-c）。计算低密度脂蛋白胆固醇（LDL-c）、残余胆固醇和非高密度脂蛋白胆固醇。在 2692 名儿童 6 岁（中位数 6.0 岁[90%范围 5.7；7.5]）和 1673 名儿童 10 岁（中位数 9.7 岁[90%范围 9.5；10.3]）时测定相应的脂质测量值。使用多元线性回归分析来检查妊娠早期母体脂质水平与产后 6 岁和 10 岁时相应的儿童脂质测量值之间的关系，同时调整混杂因素。
妊娠早期的母体脂质水平与产后 6 岁和 10 岁时相应的儿童脂质水平呈正相关，独立于母体 BMI 和饮食。
妊娠早期的母体脂质水平可能为多年后儿童的脂质谱提供了一个了解。因此，妊娠期间的脂质水平可以作为儿童长期健康的早期预测指标。监测这些妊娠期间的脂质水平可能为开始早期干预以降低后代的脂质水平并可能降低其日后心血管风险提供机会。需要进一步的研究来调查妊娠期间母体脂质水平和多年后后代的脂质水平的遗传贡献。
