人尿中谷胱甘肽-椭圆玫瑰树碱缀合物的分离与鉴定
Isolation and characterization of the glutathione-elliptinium conjugate in human urine.
作者信息
Gouyette A, Voisin E, Auclair C, Paoletti C
机构信息
Service de Pharmacologie Clinique, Institut Gustave-Roussy, Villejuif, France.
出版信息
Anticancer Res. 1987 Jul-Aug;7(4B):823-7.
PMID:3674767
Abstract
In a cancer patient given 100 mg/m2 elliptinium by intravenous infusion, the glutathione conjugate was found in urine. This metabolite was isolated after ion-exchange treatment and high performance liquid chromatography. Its structure was assessed by fast-atom bombardment mass spectrometry and comparison with an authentic sample.
摘要
在一名接受100 mg/m² 椭圆玫瑰树碱静脉输注的癌症患者尿液中发现了谷胱甘肽缀合物。该代谢产物经离子交换处理和高效液相色谱法分离。通过快原子轰击质谱法并与标准样品比较对其结构进行了评估。
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