Lyssikatos Charalampos, Wang Zhiying, Liu Ziyue, Warden Stuart, Brotto Marco, Bonewald Lynda
Indiana University.
The University of Texas at Arlington.
Res Sq. 2023 Jan 23:rs.3.rs-2492688. doi: 10.21203/rs.3.rs-2492688/v1.
As both L- and D-BAIBA are increased with exercise, we sought to determine if circulating levels would be associated with physical performance.
Serum levels of L- and D-BAIBA were quantified in 120 individuals (50% female) aged 20-85 years and categorized as either a "low" (LP), "average"(AP) or "high" performer (HP).Association analysis was performed using Spearman (S) and Pearson (P) rank correlation.
Using the Spearman (S) rank correlation, L-BAIBA positively associated with BMI (0.23) and total fat mass (0.19) in the 120 participants, with total fat mass in the 60 males (0.26) but with both BMI (0.26) and BMD (0.28) in the 60 females. In the HP females, L-BAIBA positively associated with BMD (0.50) and lean mass (0.47).Using the Pearson (P) rank correlation D-BAIBA was positively associated with age (0.20) in the 120 participants and in the LP females (0.49). D-BAIBA associated with gait speed (S 0.20) in the 120 participants. In HP males, this enantiomer had a negative association with appendicular lean/height (S -0.52) and in the AP males with BMD (S -0.47). No associations were observed in HP or AP females, whereas, in LP females, in addition to a positive association with age, a positive association was observed with grip strength (S 0.45), but a negative with BMD (P -0.52, S -0.63) and chair stands (P -0.47, S -0.51).
L-BAIBA may play a role in BMI and BMD in females, not males, whereas D-BAIBA may be a marker for aging.
由于左旋和右旋β-氨基异丁酸（L-和D-BAIBA）均会随着运动而增加，我们试图确定其循环水平是否与身体机能相关。
对120名年龄在20至85岁之间的个体（50%为女性）的血清L-和D-BAIBA水平进行定量，并将其分为“低”（LP）、“中等”（AP）或“高”表现者（HP）。使用Spearman（S）和Pearson（P）等级相关性进行关联分析。
在120名参与者中，使用Spearman（S）等级相关性分析，L-BAIBA与BMI（0.23）和总脂肪量（0.19）呈正相关，在60名男性中与总脂肪量呈正相关（0.26），而在60名女性中与BMI（0.26）和骨密度（BMD）（0.28）均呈正相关。在高表现女性中，L-BAIBA与骨密度（0.50）和去脂体重（0.47）呈正相关。使用Pearson（P）等级相关性分析，在120名参与者以及低表现女性（0.49）中，D-BAIBA与年龄呈正相关（0.20）。在120名参与者中，D-BAIBA与步速相关（S 0.20）。在高表现男性中，这种对映体与上肢去脂体重/身高呈负相关（S -0.52），在中等表现男性中与骨密度呈负相关（S -0.47）。在高表现或中等表现女性中未观察到相关性，而在低表现女性中，除了与年龄呈正相关外，还观察到与握力呈正相关（S 0.45），但与骨密度呈负相关（P -0.52，S -0.63）以及与从椅子上站起的能力呈负相关（P -0.47，S -0.51）。
L-BAIBA可能在女性而非男性的BMI和骨密度方面发挥作用，而D-BAIBA可能是衰老的一个标志物。
