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溶骨性病变:多发性骨髓瘤还是前列腺癌?

Osteolytic lesions: Multiple myeloma or prostate cancer?

作者信息

Devaraj Akshitha, Al-Sader Hassen

机构信息

Watford General Hospital, Vicarage Rd., Watford, Hertfordshire, WD18 0HB, UK.

出版信息

Radiol Case Rep. 2023 Feb 2;18(4):1485-1489. doi: 10.1016/j.radcr.2023.01.054. eCollection 2023 Apr.

DOI:10.1016/j.radcr.2023.01.054
PMID:36747906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9898297/
Abstract

Multiple myeloma is a cancer which is characterized by proliferation of malignant B-cells and plasma cell infiltration of bone marrow. Lytic lesions are one of its hallmarks, on radiological assessment. We report 2 cases who presented within 1 year to our hospital with bony lytic lesions on CT scan. They were investigated for multiple myeloma; however, there were no further features to suggest this. Both patients were confirmed to have prostate cancer. This is unusual as prostate cancer produces sclerotic lesions (unusual hardening or thickening of the bone).

摘要

多发性骨髓瘤是一种以恶性B细胞增殖和骨髓浆细胞浸润为特征的癌症。在影像学评估中,溶骨性病变是其特征之一。我们报告2例在1年内到我院就诊的患者,CT扫描显示有骨溶骨性病变。他们接受了多发性骨髓瘤的检查;然而,没有进一步的特征提示为此病。两名患者均被确诊为前列腺癌。这很不寻常,因为前列腺癌会产生硬化性病变(骨骼异常硬化或增厚)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/865a3c10672b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/a9b5b132fd17/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/fb81c582106a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/865a3c10672b/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/a9b5b132fd17/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/fb81c582106a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/076d/9898297/865a3c10672b/gr3.jpg

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本文引用的文献

1
Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention.长链非编码 RNA 在前列腺癌中的分子特征:干预途径和治疗靶点的关注。
J Exp Clin Cancer Res. 2022 Jul 1;41(1):214. doi: 10.1186/s13046-022-02406-1.
2
Guidelines on the diagnosis, investigation and initial treatment of myeloma: a British Society for Haematology/UK Myeloma Forum Guideline.骨髓瘤诊断、检查及初始治疗指南:英国血液学学会/英国骨髓瘤论坛指南
Br J Haematol. 2021 Apr;193(2):245-268. doi: 10.1111/bjh.17410. Epub 2021 Mar 21.
3
Prostate Cancer and Bone Metastases: The Underlying Mechanisms.
前列腺癌与骨转移:潜在机制。
Int J Mol Sci. 2019 May 27;20(10):2587. doi: 10.3390/ijms20102587.
4
Prostate carcinoma presenting with diffuse osteolytic metastases and supraclavicular lymphadenopathy mimicking multiple myeloma.表现为弥漫性溶骨性转移和锁骨上淋巴结病、酷似多发性骨髓瘤的前列腺癌。
Clin Case Rep. 2017 Dec 19;6(2):253-257. doi: 10.1002/ccr3.1336. eCollection 2018 Feb.
5
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.国际骨髓瘤工作组更新了多发性骨髓瘤的诊断标准。
Lancet Oncol. 2014 Nov;15(12):e538-48. doi: 10.1016/S1470-2045(14)70442-5. Epub 2014 Oct 26.
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Bone disease in multiple myeloma: pathophysiology and management.多发性骨髓瘤中的骨病:病理生理学与管理
Cancer Growth Metastasis. 2014 Aug 10;7:33-42. doi: 10.4137/CGM.S16817. eCollection 2014.
7
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8
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J Nucl Med. 2011 Jan;52(1):81-9. doi: 10.2967/jnumed.110.077941. Epub 2010 Dec 13.
10
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