Minezaki Teruumi, Hattori Takaaki, Shibata Motoko, Nakagawa Hayate, Kumakura Shigeto, Goto Hiroshi
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Int Med Case Rep J. 2023 Jan 31;16:83-89. doi: 10.2147/IMCRJ.S394715. eCollection 2023.
To report seven eyes of six patients diagnosed with corneal perforation and lacrimal canaliculitis in a single facility.
Clinical records of patients with corneal perforation accompanied by lacrimal canaliculitis seen by the authors were reviewed.
Six patients (7 eyes) with corneal perforation accompanied by lacrimal canaliculitis were identified. All patients were female, and all were treated with topical antibiotics while five were receiving topical corticosteroids. Two patients had a history of dacryocystitis and three had systemic immune diseases. The corneal lesions did not respond to topical antibiotics but were effectively treated by removal of concretions in the lacrimal canaliculi and lacrimal duct drainage together with conjunctival autograft or corneal transplantation.
Lacrimal canaliculitis is a risk factor for corneal perforation. When corneal perforation does not respond to antibiotics, lacrimal canaliculitis should be considered.
报告在单一机构中诊断为角膜穿孔合并泪小管炎的6例患者的7只眼。
回顾作者所诊治的伴有泪小管炎的角膜穿孔患者的临床记录。
确定了6例(7只眼)伴有泪小管炎的角膜穿孔患者。所有患者均为女性,均接受局部抗生素治疗,其中5例同时接受局部皮质类固醇治疗。2例有泪囊炎病史,3例有全身性免疫疾病。角膜病变对局部抗生素治疗无反应,但通过清除泪小管结石、泪道引流以及结膜自体移植或角膜移植得到有效治疗。
泪小管炎是角膜穿孔的危险因素。当角膜穿孔对抗生素无反应时,应考虑泪小管炎。