Tomczyk Katarzyna M, Rzymski Pawel, Wilczak Maciej
Department of Mother and Child Health, Poznan University of Medical Sciences, Poznan, Poland.
Ginekol Pol. 2022;93(10):806-810. doi: 10.5603/GP.a2022.0088.
Among the main adverse environmental factors, we usually distinguish the impact of heavy metals, especially Cd and Pb. Apart from the carcinogenic and toxic properties, their potential, stimulating estrogen receptors effect (metaloestrogens) is strongly emphasized; as well as participation in gene regulation mechanisms (epigenetic). The aim of this study is to examine if there is a special scheme of concentrations of heavy metals accumulated in the female endometrium in certain pathologies: endometrial hyperplasia, endometrial cancer, endometrial polyps and miscarriages. The control group consisted of patients with abnormal uterine bleeding or functional bleeding with correct histopathological findings.
The study was performed on 92 women. Microwave induced plasma atomic emission spectrometry was used to assess metals concentrations in tissue material and the results of obtained concentrations were converted to μg/kg. The calculations were performed using discriminant and canonical analyses and revealed four discriminant functions.
The results showed that metal's tissue concentrations vary in different types of histopathological diagnosis and the scheme of concentrations might be characteristic for analyzed diagnosis. Pb and Al has the most substantial impact on discrimination.
Endometrium may accumulate toxic metals such as: Pb, Cd, Ni, Mn, Cu, Zn, Al, Cr. It can be assumed that there are characteristic distributions of toxic metals concentrations for individual histopathological diagnoses.
在主要的不良环境因素中，我们通常会区分重金属的影响，尤其是镉和铅。除了致癌和毒性特性外，它们潜在的刺激雌激素受体的作用（金属雌激素）以及参与基因调控机制（表观遗传学）也受到了强烈关注。本研究的目的是检查在某些病理情况下，女性子宫内膜中积累的重金属浓度是否存在特殊模式：子宫内膜增生、子宫内膜癌、子宫内膜息肉和流产。对照组由子宫异常出血或功能性出血且组织病理学检查结果正常的患者组成。
对92名女性进行了研究。采用微波诱导等离子体原子发射光谱法评估组织材料中的金属浓度，并将所得浓度结果换算为μg/kg。使用判别分析和典型分析进行计算，得出了四个判别函数。
结果表明，不同组织病理学诊断类型中金属的组织浓度有所不同，浓度模式可能是所分析诊断的特征。铅和铝对判别影响最大。
子宫内膜可能会积累有毒金属，如：铅、镉、镍、锰、铜、锌、铝、铬。可以假定，对于个体组织病理学诊断，有毒金属浓度存在特征性分布。
