Li Chen, Wu Xiaoyan, Wang Xiaoli, Shi Jianli, Liu Chang, Peng Zhe, Han Hong, Xu Shaojian, Wang Shuo, Ma Yingru, Zheng Limei, Hrabchenko Nataliia, Li Jun
Shandong Provincial Key Laboratory of Animal Disease Control and Breeding, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, PR China.
College of Life Sciences, Shandong Normal University, Jinan, PR China.
J Gen Virol. 2022 Nov;103(11). doi: 10.1099/jgv.0.001788.
Senecavirus A (SVA), formerly called Seneca Valley virus (SVV) was first isolated from the USA in 2002. This study isolated an SVA strain from a pig herd in Shandong Province, PR China and designated it SVA-CH-SDGT-2017. The full-length genome, excluding the poly(A) tails of the SVA isolates, was 7280 nucleotides long, with the genomic organization resembling and sharing high nucleotide identities of 90.7-96.9 % with other previously reported SVA isolates. To investigate the pathogenicity of the SVA isolates, experimental infections of pigs were performed. The SVA strains successfully infected the pigs, as evidenced by the presence of virus shedding and robust serum neutralizing antibody responses. In addition, the contact-exposed experiment showed that the virus shedding of the contact-exposed pigs was approximately a 100-fold reduced compared to that of the inoculated group, indicating that the virus is capable of transmission to pigs. Our findings provide useful data for studying the pathogenesis and transmission of SVA in pigs.
A组赛内卡病毒（SVA），以前称为塞内卡山谷病毒（SVV），于2002年首次在美国分离出来。本研究从中国山东省的一个猪群中分离出一株SVA毒株，并将其命名为SVA-CH-SDGT-2017。SVA分离株的全长基因组（不包括poly(A)尾）长度为7280个核苷酸，其基因组结构与其他先前报道的SVA分离株相似，核苷酸同源性高达90.7-96.9%。为了研究SVA分离株的致病性，对猪进行了实验性感染。SVA毒株成功感染了猪，病毒排毒和强烈的血清中和抗体反应证明了这一点。此外，接触暴露实验表明，接触暴露猪的病毒排毒量比接种组减少了约100倍，表明该病毒能够传播给猪。我们的研究结果为研究SVA在猪中的发病机制和传播提供了有用的数据。
