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乳腺脓肿的相关情况:一项回顾性队列研究

breast abscesses in context, a retrospective cohort study.

作者信息

Stevenson Daniel R, Das Satya, Lambourne Jonathan, Ledwidge Serena F C, Johnson Laura, Rosmarin Caryn

机构信息

Department of Medical Microbiology, Division of Infection, Barts Health NHS Trust, London, UK.

Queen Mary University of London, London E1 4NS, UK.

出版信息

J Med Microbiol. 2022 Dec;71(12). doi: 10.1099/jmm.0.001616.

Abstract

breast abscesses and granulomatous mastitis have gained increased recognition in the 20 years since their association was first described. No studies to date have described this organism in the context of all breast abscess pathogens. We retrospectively reviewed 160 community-acquired breast abscess samples from 135 patients in a 3 year period, describing the organisms isolated along with risk factors, site of infection and outcomes. We compared patient subgroups with acute and chronic abscesses, the latter defined as having a requirement for repeat aspiration more than 1 month apart. The prevalence of breast abscesses was 8 % in all patients (11/135), rising to 32 % in chronic abscesses (10/31), but only 1 % in acute abscesses (1/104; <0.01). Only 10 % (1/10) of patients with chronic abscesses were smokers, whereas 75 % of patients (15/20) with non- chronic abscesses were smokers (=0.01). should be considered in recurrent and prolonged infections, especially in non-smokers, and diagnostic methods altered accordingly. Identifying provides diagnostic clarity and alters management with recommendations for longer courses of treatment using non-beta-lactam antibiotics.

摘要

自首次描述乳腺脓肿和肉芽肿性乳腺炎的关联以来的20年里,它们已得到越来越多的认识。迄今为止,尚无研究在所有乳腺脓肿病原体的背景下描述这种病原体。我们回顾性分析了3年内135例患者的160份社区获得性乳腺脓肿样本,描述了分离出的病原体以及危险因素、感染部位和结局。我们比较了急性和慢性脓肿患者亚组,后者定义为需要间隔1个月以上重复穿刺抽吸。乳腺脓肿在所有患者中的患病率为8%(11/135),在慢性脓肿中升至32%(10/31),但在急性脓肿中仅为1%(1/104;<0.01)。慢性脓肿患者中只有10%(1/10)是吸烟者,而非慢性脓肿患者中有75%(15/20)是吸烟者(P=0.01)。对于复发性和持续性感染,尤其是非吸烟者,应考虑到这一点,并相应改变诊断方法。识别这种病原体可提供诊断清晰度,并改变治疗方案,建议使用非β-内酰胺类抗生素进行更长疗程的治疗。

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