《医学微生物学杂志》简介：甲型流感病毒：一种具有大流行潜力的被忽视的病毒。

JMM Profile: Swine influenza A virus: a neglected virus with pandemic potential.

作者信息

Mollett Benjamin C, Everett Helen E, van Diemen Pauline M, Byrne Alexander M P, Ramsay Andrew, James Joe, Reid Scott M, Hansen Rowena D E, Lewis Nicola S, Brown Ian H, Banyard Ashley C

机构信息

Department of Virology, Animal and Plant Health Agency (APHA), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.

WOAH/FAO International Reference Laboratory for Avian Influenza and Swine Influenza, Animal and Plant Health Agency (APHA), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.

出版信息

J Med Microbiol. 2023 Jan;72(1). doi: 10.1099/jmm.0.001623.

DOI:10.1099/jmm.0.001623

PMID:36748620

Abstract

Swine influenza is an acute respiratory disease of swine caused by swine influenza A virus (SwIAV). The ability of SwIAV to spread bidirectionally from animals to humans (zoonotic), and from humans to animals (reverse zoonotic), drives coinfection that can result in gene segment exchange and elevates the risk of generating viruses with pandemic potential. Compared to human-origin influenza A viruses, current data indicate a greater diversity amongst circulating SwIAVs, with three major subtypes (classified by haemagglutinin and neuraminidase) circulating globally in swine (H1N1, H1N2 and H3N2). The lack of protection afforded by human seasonal influenza vaccines against SwIAVs exacerbates the risk associated with reassortment of human, swine and potentially avian viruses. As such, global monitoring of SwIAVs is important for both human and animal health as they represent a true 'One Health' challenge with pandemic potential.

摘要

猪流感是由甲型猪流感病毒（SwIAV）引起的猪的一种急性呼吸道疾病。SwIAV在动物与人类之间双向传播（人畜共患病传播）以及在人类与动物之间反向传播（反向人畜共患病传播）的能力，导致了共感染，这可能会引发基因片段交换，并增加产生具有大流行潜力病毒的风险。与源自人类的甲型流感病毒相比，目前的数据表明，在流行的SwIAV中存在更大的多样性，全球猪群中流行着三种主要亚型（根据血凝素和神经氨酸酶分类）（H1N1、H1N2和H3N2）。人类季节性流感疫苗对SwIAV缺乏保护作用，这加剧了人类、猪以及潜在禽流感病毒重配所带来的风险。因此，对SwIAV进行全球监测对人类和动物健康都很重要，因为它们代表了一个具有大流行潜力的真正的“同一健康”挑战。