[新生儿白血病与蓝莓松饼宝宝综合征：关于一例21三体综合征病例]
[Neonatal leukemia and Blueberry Muffin Baby Syndrome: About a case of trisomy 21].
作者信息
Yahyaoui Hicham, Azami Mohamed Amine, El Mrimar Nadia, Raissi Abderrahim, Slitine Nadia El Idrissi, Bennaoui Fatiha, Ameur Mustapha Ait, Maoulainine Fadl Mrabih Rabih, Chakour Mohammed
机构信息
Laboratoire d'hématologie, Hôpital militaire Avicenne, Marrakech, Maroc, Faculté de médecine et de pharmacie de Marrakech, Maroc.
Laboratoire d'anatomie pathologique, Hôpital Militaire Avicenne, Marrakech, Maroc, Faculté de médecine et de pharmacie de Marrakech, Maroc.
出版信息
Ann Biol Clin (Paris). 2023 Mar 15;81(1):96-100. doi: 10.1684/abc.2023.1784.
Acute leukemias are rare disease in the neonatal period. They occur preferentially in newborns with trisomy 21. They often manifest as hepatosplenomegaly, extra-hematopoietic involvement and hyperleukocytosis. Blueberry Muffin Baby syndrome is observed in the neonatal period. Neonatal acute myeloïd leukemia (AML) is more common than acute lymphoid leukemia (ALL). Despite treatment, neonatal acute leukemias have a poor prognosis with a low percentage of overall survival. We report a case of neonatal AML on a ground of trisomy 21 revealed by a Blueberry Muffin Baby syndrome.
急性白血病在新生儿期是罕见疾病。它们更易发生于患有21三体综合征的新生儿。常表现为肝脾肿大、造血外浸润和白细胞增多。在新生儿期可观察到蓝莓松饼宝宝综合征。新生儿急性髓细胞白血病（AML）比急性淋巴细胞白血病（ALL）更常见。尽管进行了治疗，新生儿急性白血病的预后仍然很差，总体生存率较低。我们报告一例因蓝莓松饼宝宝综合征而发现的、基于21三体综合征的新生儿AML病例。
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