Department of Religions and Philosophies, University of London, London, United Kingdom.
Department of Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.
J Integr Complement Med. 2023 Apr;29(4):224-233. doi: 10.1089/jicm.2022.0713. Epub 2023 Feb 7.
The stress and psychological factors affect the human transcriptomic and epigenomic landscapes. meditation (PM) was found to be effective, in novice healthy college student meditators, at the cognitive skills and transcriptomic levels. Recently published data showed that PM induced alterations at the transcriptome level in healthy and novice college students. To decipher potential mechanisms underlying the PM effect at the cellular level, array-based methylation analyses in peripheral blood were performed at baseline and 8 weeks postintervention in 34 participants. Overall, 470 CpG sites were nominally differentially methylated ( ≤ 0.05 and change magnitude from ≥3% to ≤ -3%) between baseline and 8 weeks postintervention with 180 sites hypermethylated and 290 sites hypomethylated. Pathway analysis of the genes linked to the differentially methylated sites revealed the enrichment of several molecular and cellular signaling pathways, especially metabolic and brain function signaling pathways. Besides its beneficial effects on cognitive skills and transcriptome alterations, the current data indicate that PM meditation also affects the DNA methylation profile of novice and healthy college students 8 weeks postintervention. NCT03779269.
压力和心理因素会影响人类的转录组和表观基因组图谱。冥想（PM）被发现对新手健康大学生冥想者的认知技能和转录组水平有效。最近发表的数据显示，PM 会在健康和新手大学生的转录组水平上引起变化。为了解释 PM 对细胞水平的影响的潜在机制，在 34 名参与者中，在基线和干预后 8 周时，使用基于阵列的甲基化分析进行了外周血分析。总体而言，基线与干预后 8 周之间有 470 个 CpG 位点差异甲基化（≤0.05，变化幅度为≥3%至≤-3%），其中 180 个位点超甲基化，290 个位点低甲基化。与差异甲基化位点相关的基因的通路分析显示，多个分子和细胞信号通路，特别是代谢和大脑功能信号通路，得到了富集。除了对认知技能和转录组变化有益外，目前的数据还表明，PM 冥想还会影响新手和健康大学生干预后 8 周的 DNA 甲基化谱。NCT03779269。
