Xu Baida, Chen Ke, Su Wentao, Liu Yehong, Sheng Ying, Ye Ting, Wu Gangyong, Zong Gangjun
Department of Cardiology, The 904Th Hospital of Joint Logistic Support Force of PLA, Wuxi, 214044, China.
Wuxi Clinical College of Anhui Medical University, Wuxi, China.
J Cardiovasc Transl Res. 2023 Aug;16(4):938-947. doi: 10.1007/s12265-023-10358-w. Epub 2023 Feb 7.
We aimed to explore the correlation among serum GDF11, the severity of coronary artery lesions, and the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). A total of 367 patients were enrolled and divided into control (n = 172) and STEMI (n = 195) groups. Serum GDF11 (P < 0.001) was an independent predictor of STEMI and was negatively correlated with SYNTAX score (P < 0.05). ROC curve analysis showed that serum GDF11 could screen patients for major adverse cardiovascular events (MACEs). KM curve analysis showed that patients with lower concentration of GDF11 had a higher incidence of MACEs, and Cox proportional hazards regression analysis showed that the serum GDF11 (P < 0.001) was an independent predictor of MACEs. Serum GDF11 was negatively correlated with the severity of coronary lesions and was also an independent prognostic indicator of MACEs in patients with STEMI.
我们旨在探讨血清生长分化因子11（GDF11）、冠状动脉病变严重程度与ST段抬高型心肌梗死（STEMI）患者预后之间的相关性。共纳入367例患者，分为对照组（n = 172）和STEMI组（n = 195）。血清GDF11（P < 0.001）是STEMI的独立预测因子，且与SYNTAX评分呈负相关（P < 0.05）。ROC曲线分析表明，血清GDF11可用于筛查主要不良心血管事件（MACE）患者。KM曲线分析显示，GDF11浓度较低的患者发生MACE的发生率较高，Cox比例风险回归分析表明，血清GDF11（P < 0.001）是MACE的独立预测因子。血清GDF11与冠状动脉病变严重程度呈负相关，也是STEMI患者MACE的独立预后指标。
