School of Life Science, Jiangxi Science and Technology Normal University, Nanchang, China.
J Biomater Appl. 2023 Apr;37(9):1555-1567. doi: 10.1177/08853282231156316. Epub 2023 Feb 7.
Drugs with different solubility can be selectively embedded into polymersomes with the hydrophilic core and hydrophobic bilayer. Novel folate-targeted Pluronic/poly (D,L-lactide--glycolide) polymersomes were constructed and used for the co-delivery of paclitaxel (PTX) and doxorubicin (DOX) to improve their inhibitory effect over cancer cells. The particle size of blank polymersomes was mainly distributed below 125 nm. The release of PTX and DOX from polymersomes showed an initial burst release followed by a sustained and slow release. The in vitro cytotoxicity data showed that the targeted co-loaded polymersomes (PTX&DOX FA-Ps) exhibited better inhibitory effect than single-loaded polymersomes and free drugs did. Furthermore, PTX&DOX FA-Ps showed the synergistic therapeutic effect over OVCAR-3 cancer cells. The cellular uptake results also showed that folate modified polymersomes had excellent targeting performance. Therefore, the folate-targeted Pluronic/poly (D,L-lactide--glycolide) polymersomes have potential application value as novel drug carriers to co-deliver PTX and DOX.
具有不同溶解度的药物可以选择性地嵌入具有亲水性核心和疏水性双层的聚合物囊泡中。构建了新型叶酸靶向泊洛沙姆/聚（D，L-乳酸-共-乙醇酸）聚合物囊泡，用于共同递送紫杉醇（PTX）和阿霉素（DOX），以提高其对癌细胞的抑制作用。空白聚合物囊泡的粒径主要分布在 125nm 以下。PTX 和 DOX 从聚合物囊泡中的释放表现出初始突释，随后是持续缓慢的释放。体外细胞毒性数据表明，靶向共载聚合物囊泡（PTX&DOX FA-Ps）比单载聚合物囊泡和游离药物具有更好的抑制作用。此外，PTX&DOX FA-Ps 对 OVCAR-3 癌细胞表现出协同治疗效果。细胞摄取结果还表明，叶酸修饰的聚合物囊泡具有优异的靶向性能。因此，叶酸靶向泊洛沙姆/聚（D，L-乳酸-共-乙醇酸）聚合物囊泡作为新型药物载体，具有共同递送 PTX 和 DOX 的潜在应用价值。
