Department of Experimental Immunology, Amsterdam Institute for Infection and Immunity, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Neuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands.
Basic Clin Pharmacol Toxicol. 2023 Oct;133(4):286-294. doi: 10.1111/bcpt.13841. Epub 2023 Feb 17.
GPR56/ADGRG1 is an adhesion G protein-coupled receptor connected to brain development, haematopoiesis, male fertility, and tumorigenesis. Nevertheless, expression of GPR56 is not restricted to developmental processes. Studies over the last years have demonstrated a marked presence of GPR56 in human cytotoxic NK and T cells. Expression of GPR56 in these cells is driven by the transcription factor HOBIT, corresponds with the production of cytolytic mediators and the presence of CX CR1 and CD57, indicates a state of terminal differentiation and cellular exhaustion, and disappears upon cellular activation. Functional studies indicate that GPR56 regulates cell migration and effector functions and thereby acts as an inhibitory immune checkpoint. We here discuss the current state of knowledge regarding GPR56 in cytotoxic lymphocytes.
GPR56/ADGRG1 是一种黏附 G 蛋白偶联受体，与大脑发育、造血、男性生育能力和肿瘤发生有关。然而，GPR56 的表达不仅局限于发育过程。近年来的研究表明，GPR56 在人类细胞毒性 NK 和 T 细胞中大量存在。这些细胞中 GPR56 的表达受转录因子 HOBIT 的驱动，与细胞毒性介质的产生以及 CXCR1 和 CD57 的存在相对应，表明处于终末分化和细胞耗竭状态，在细胞激活时消失。功能研究表明，GPR56 调节细胞迁移和效应功能，因此作为一种抑制性免疫检查点发挥作用。本文讨论了细胞毒性淋巴细胞中 GPR56 的最新研究进展。
Basic Clin Pharmacol Toxicol. 2023-10
J Leukoc Biol. 2011-7-1
Zotero 插件