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TREM 受体的生物学。

The biology of TREM receptors.

机构信息

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

出版信息

Nat Rev Immunol. 2023 Sep;23(9):580-594. doi: 10.1038/s41577-023-00837-1. Epub 2023 Feb 7.

DOI:10.1038/s41577-023-00837-1
PMID:36750615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9904274/
Abstract

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages. These receptors have been implicated in inflammation, neurodegenerative diseases, bone remodelling, metabolic syndrome, atherosclerosis and cancer. Here, I review the structure, ligands, signalling modes and functions of TREMs in humans and mice and discuss the challenges that remain in understanding TREM biology.

摘要

触发表达于髓样细胞的受体（TREMs）包含一组主要由粒细胞、单核细胞和组织巨噬细胞表达的细胞表面受体。这些受体已被牵涉到炎症、神经退行性疾病、骨重塑、代谢综合征、动脉粥样硬化和癌症中。在此，我综述了人类和小鼠 TREMs 的结构、配体、信号模式和功能，并讨论了在理解 TREM 生物学方面仍然存在的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/658b887e6df5/41577_2023_837_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/835966973f77/41577_2023_837_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/70695e065d47/41577_2023_837_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/d1cfe27a502a/41577_2023_837_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/658b887e6df5/41577_2023_837_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/835966973f77/41577_2023_837_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/70695e065d47/41577_2023_837_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/d1cfe27a502a/41577_2023_837_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b578/9904274/658b887e6df5/41577_2023_837_Fig4_HTML.jpg

相似文献

[1]
The biology of TREM receptors.

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[2]
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[3]
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[4]
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[5]
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[6]
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[8]
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[10]
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[4]
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[5]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.

Cell. 2022-10-27

[2]
SYK coordinates neuroprotective microglial responses in neurodegenerative disease.

Cell. 2022-10-27

[3]
Exon 2-mediated deletion of Trem2 does not worsen metabolic function in diet-induced obese mice.

J Physiol. 2022-10

[4]
TREM2 macrophages induced by human lipids drive inflammation in acne lesions.

Sci Immunol. 2022-7-22

[5]
Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer.

Cancer Res. 2022-9-16

[6]
Soluble TREM2 levels reflect the recruitment and expansion of TREM2 macrophages that localize to fibrotic areas and limit NASH.

J Hepatol. 2022-11

[7]
Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease.

Cell Rep. 2022-5-31

[8]
N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.

Int J Mol Sci. 2022-5-20

[9]
Integrated Analysis Highlights the Immunosuppressive Role of TREM2 Macrophages in Hepatocellular Carcinoma.

Front Immunol. 2022-3-14

[10]
Tissue-resident FOLR2 macrophages associate with CD8 T cell infiltration in human breast cancer.

Cell. 2022-3-31

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