Minnesota Population Center, University of Minnesota, Minneapolis, MN, USA.
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
J Aging Health. 2023 Oct;35(9):688-698. doi: 10.1177/08982643231155997. Epub 2023 Feb 7.
We investigated the relationship between the cognitive status of participants' spouses and participants' own cognitive outcomes, controlling for mid-life factors. Participants ( = 1845; baseline age 66-90 years) from the prospective Atherosclerosis Risk in Communities Study were followed from 2011 to 2019. We used linear regression and Cox proportional hazard models to estimate whether spouses of people with MCI/dementia had lower cognitive functioning and elevated risk of incident dementia. Having a spouse with MCI/dementia was associated with a deficit in cognitive function (b = -0.09 standard deviations; 95% CI = -0.18, 0.00). Adjustment for mid-life risk factors attenuated this association (b = -0.02 standard deviations; 95% CI = -0.10, 0.06). We observed no significant relationship between spousal MCI/dementia status and incident dementia (hazard ratio = 0.97; 95% CI = 0.69, 1.38). Spousal cognitive status is not associated with poor cognitive outcomes independent of mid-life factors.
我们调查了参与者配偶的认知状态与参与者自身认知结果之间的关系，控制了中年期因素。参与者（n=1845；基线年龄 66-90 岁）来自前瞻性的社区动脉粥样硬化风险研究，从 2011 年随访到 2019 年。我们使用线性回归和 Cox 比例风险模型来估计是否轻度认知障碍/痴呆症患者的配偶认知功能较低且痴呆症发病风险升高。配偶患有轻度认知障碍/痴呆症与认知功能缺陷相关（b = -0.09 标准差；95%CI = -0.18, 0.00）。调整中年期危险因素后，这种关联减弱（b = -0.02 标准差；95%CI = -0.10, 0.06）。我们没有观察到配偶轻度认知障碍/痴呆症状况与痴呆症发病之间存在显著关系（危险比=0.97；95%CI = 0.69, 1.38）。配偶的认知状态与中年期因素无关，与较差的认知结果无关。
