Medical School of Southeast University, Southeast University, Nanjing 210009, China.
Department of Spine Surgery, Zhongda Hospital Affiliated to Southeast University, School of Medicine, Southeast University, Nanjing 210009, China.
J Zhejiang Univ Sci B. 2023 Feb 15;24(2):115-129. doi: 10.1631/jzus.B2200410.
Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells, but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period. Hence, strategies to increase the efficacy of MSC treatment are urgently needed. Iron overload, reactive oxygen species deposition, and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs, thereby hastening cell death. Notably, oxidative stress (OS) and deficient antioxidant defense induced by iron overload can result in ferroptosis. Ferroptosis may inhibit cell survival after MSC transplantation, thereby reducing clinical efficacy. In this review, we explore the role of ferroptosis in MSC performance. Given that little research has focused on ferroptosis in transplanted MSCs, further study is urgently needed to enhance the in vivo implantation, function, and duration of MSCs.
体外培养扩增的间充质干细胞（MSCs）因其具有修复组织损伤的能力而受到研究关注。MSC 移植是促进受损组织修复、替代丢失细胞或保护存活细胞的有效方法，但目前 MSC 移植的效率受到移植后短时间内大量 MSC 丢失的限制。因此，迫切需要增加 MSC 治疗效果的策略。铁过载、活性氧沉积和抗氧化能力下降抑制 MSC 的增殖和再生，从而加速细胞死亡。值得注意的是，铁过载引起的氧化应激（OS）和抗氧化防御不足会导致铁死亡。铁死亡可能会抑制 MSC 移植后的细胞存活，从而降低临床疗效。在本综述中，我们探讨了铁死亡在 MSC 性能中的作用。鉴于铁死亡在移植 MSC 中的研究较少，迫切需要进一步研究以增强 MSC 的体内植入、功能和持续时间。
