Division of Neuropsychology, Children's National Hospital, Washington, D.C.
Departments of Psychiatry and Behavioral Sciences & Pediatrics at The George Washington University School of Medicine.
Child Neuropsychol. 2023 Nov;29(7):1128-1154. doi: 10.1080/09297049.2023.2173162. Epub 2023 Feb 8.
Children with congenital heart disease (CHD) are at increased risk for neurodevelopmental challenges across the lifespan. These are associated with neurological changes and potential acquired brain injury, which occur across a developmental trajectory and which are influenced by an array of medical, sociodemographic, environmental, and personal factors. These alterations to brain development lead to an array of adverse neurodevelopmental outcomes, which impact a characteristic set of skills over the course of development. The current paper reviews existing knowledge of aberrant brain development and brain injury alongside associated neurodevelopmental challenges across the lifespan. These provide a framework for discussion of emerging and potential interventions to improve neurodevelopmental outcomes at each developmental stage.
患有先天性心脏病 (CHD) 的儿童在整个生命周期中都面临神经发育挑战的风险增加。这些挑战与神经变化和潜在的获得性脑损伤有关，这些变化发生在整个发育轨迹中，并受到一系列医疗、社会人口、环境和个人因素的影响。这些对大脑发育的改变导致了一系列不良的神经发育结果，这些结果在发育过程中影响了一组特定的技能。本文综述了现有关于异常大脑发育和脑损伤以及整个生命周期中相关神经发育挑战的知识。这些为讨论在每个发育阶段改善神经发育结果的新兴和潜在干预措施提供了框架。
