Chumakov A M, Kuznetsov S V, Daurova N V
Arkh Patol. 1987;49(8):58-64.
Morphofunctional studies of parietal and gastrin-producing cells in 30 children with chronic gastroduodenitis with (10 patients) or without (20) recurrent erosions in the pyloroduodenal region showed functional inhibition of G cells and hyperplasia of P cells in the antral part of the stomach in children with recurring erosions. In these children, the increased surface area and density of parietal cells, the increased perimeters of secretory canaliculi's membranes, and the consequent elevated gastric juice acidity were probably due to P-cell hyperplasia in the gastric antrum and G-cell hyperplasia in the duodenal bulb. In children, gastroduodenitis with recurrent erosions should be considered a pathogenetic variant of duodenal ulcerous disease.
对30例患有慢性胃十二指肠炎症的儿童进行壁细胞和胃泌素分泌细胞的形态功能研究，其中10例患者幽门十二指肠区域有复发性糜烂，20例没有。结果显示，有复发性糜烂的儿童胃窦部G细胞功能受到抑制，P细胞增生。在这些儿童中，壁细胞表面积和密度增加、分泌小管膜周长增加，以及由此导致的胃液酸度升高，可能是由于胃窦部P细胞增生和十二指肠球部G细胞增生所致。在儿童中，伴有复发性糜烂的胃十二指肠炎症应被视为十二指肠溃疡病的一种发病机制变体。
