一例产生胰岛素样生长因子II的腹膜后脂肪肉瘤的手术切除：病例报告

Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report.

作者信息

Nishiwaki Noriyuki, Mikuriya Yoshihiro, Takatsu Fumiaki, Ochiai Ryoji, Kakishita Tomokazu, Kobayashi Naruyuki, Kobatake Takaya, Hato Shinji, Teramoto Norihiro, Nagao Mototsugu, Fukuda Izumi, Ohta Koji

机构信息

Department of Gastroenterological Surgery, National Hospital Organization, Shikoku Cancer Center, 160, Ko, Minamiumemoto-machi, Matsuyama-shi, Ehime-Ken, 791-0280, Japan.

Department of Pathology, National Hospital Organization, Shikoku Cancer Center, 160, Ko, Minamiumemoto-machi, Matsuyama-shi, Ehime-Ken, 791-0280, Japan.

出版信息

Surg Case Rep. 2023 Feb 8;9(1):19. doi: 10.1186/s40792-023-01589-9.

DOI:10.1186/s40792-023-01589-9

PMID:36752872

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9908783/

Abstract

BACKGROUND

Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that produced big insulin-like growth factor-II.

CASE PRESENTATION

Here, we report the case of a 62-year-old woman who presented with an abdominal mass and hypoglycemia. Non-islet cell tumor hypoglycemia due to retroperitoneal liposarcoma was suspected. After complete resection of the tumor, the patient's hypoglycemia improved and big insulin-like growth factor-II disappeared in the molecular weight analysis of serum insulin-like growth factor-II by western blotting. The patient had no tumor recurrence or reappearance of hypoglycemia 16 months after the operation without any adjuvant therapy.

CONCLUSIONS

Although insulin-like growth factor-II-producing tumors are generally large and difficult to operate on, surgical resection is currently the most effective and only treatment; thus, it is essential to attempt resection aggressively.

摘要

背景

肿瘤产生的高分子量胰岛素样生长因子-II（大胰岛素样生长因子-II）被认为会导致非胰岛细胞瘤性低血糖症。本文介绍了一例经手术切除的产生大胰岛素样生长因子-II的腹膜后脂肪肉瘤病例。

病例报告

在此，我们报告一例62岁女性患者，该患者出现腹部肿块和低血糖症。怀疑是腹膜后脂肪肉瘤导致的非胰岛细胞瘤性低血糖症。肿瘤完全切除后，患者的低血糖症得到改善，并且在通过蛋白质印迹法对血清胰岛素样生长因子-II进行分子量分析时，大胰岛素样生长因子-II消失。术后16个月，患者未接受任何辅助治疗，无肿瘤复发，也未再次出现低血糖症。