职业接触有机溶剂个体的癌症风险评估
[Cancer risk evaluation in individuals occupationally exposed to organic solvents].
作者信息
Hoyos-Giraldo Luz S, Ramos-Angulo Jovanna V, Reyes-Carvajal Ingrid
机构信息
LH: Bióloga. M. Sc. Salud Ocupacional. Ph. D. Ciencias Biomédicas. Grupo de Investigación en Toxicología Genética y Citogenética. Departamento de Biología. Facultad de Ciencias Naturales, Exactas y de la Educación, Universidad del Cauca, Popayán, Colombia.
JR: Bióloga. Universidad del Cauca. Popayán, Colombia,
出版信息
Rev Salud Publica (Bogota). 2020 May 1;22(3):265-279. doi: 10.15446/rsap.V22n3.80224.
OBJECTIVE
To evaluate the frequency of micronuclei (MNs) and influence of GSTM1 and GSTT1 gene polymorphisms as biomarkers of cancer risk in car painters (n=152) compared to unexposed individuals (n=152).
METHODS
Molecular epidemiology study, cross-sectional analysis of gen and environment interaction. The evaluation of MN and genetic polymorphisms was determined by molecular tests in lymphocytes from subjects involved in the study.
RESULTS
It was determined that the frequency of MNs is 1.6 higher in the exposed group compared to the reference group (1.39 ± 0.92 versus 0.87 ± 0.78, p<0.0001). There was no increase in the frequency of MNs associated with the polymorphisms in GSTM1 and GSTT1.
CONCLUSIONS
The increase of MNs in car painters serves to alert the increased risk of cancer in this population exposed to organic solvents. These results can be used in Occupational Epidemiological Surveillance Programs, as a prevention strategy and policies to regulate and control the use of solvents at a national level and in other countries with a large informal sector of individuals exposed to these chemicals to reduce the risk of cancer.
目的
评估汽车喷漆工（n = 152）与未暴露个体（n = 152）相比，微核（MNs）的频率以及谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）基因多态性作为癌症风险生物标志物的影响。
方法
分子流行病学研究，基因与环境相互作用的横断面分析。通过对参与研究的受试者淋巴细胞进行分子检测来确定MN和基因多态性。
结果
确定暴露组的MN频率比参照组高1.6倍（1.39±0.92对0.87±0.78，p<0.0001）。与GSTM1和GSTT1基因多态性相关的MN频率没有增加。
结论
汽车喷漆工中MN的增加提示该有机溶剂暴露人群患癌风险增加。这些结果可用于职业流行病学监测项目，作为一种预防策略以及在国家层面和其他有大量接触这些化学物质的非正规个体部门的国家中规范和控制溶剂使用的政策，以降低癌症风险。
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