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GDF15 类似物作为肥胖治疗药物。

GDF15 analogs as obesity therapeutics.

机构信息

St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney and University of New South Wales, Sydney, NSW 2010, Australia.

Department of Immunopathology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia.

出版信息

Cell Metab. 2023 Feb 7;35(2):227-228. doi: 10.1016/j.cmet.2023.01.002.

DOI:10.1016/j.cmet.2023.01.002
PMID:36754014
Abstract

There is increasing interest in GDF15 analogs as therapeutic agents for obesity. In this issue of Cell Metabolism, Benichou et al. report the first clinical trial of such a drug in obese humans.

摘要

人们对 GDF15 类似物作为肥胖症治疗药物的兴趣日益浓厚。在本期《细胞代谢》中,Benichou 等人报道了此类药物在肥胖人群中的首次临床试验。

相似文献

1
GDF15 analogs as obesity therapeutics.GDF15 类似物作为肥胖治疗药物。
Cell Metab. 2023 Feb 7;35(2):227-228. doi: 10.1016/j.cmet.2023.01.002.
2
Growth differentiation factor 15 as a potential therapeutic for treating obesity.生长分化因子 15 作为治疗肥胖的潜在治疗药物。
Mol Metab. 2021 Apr;46:101117. doi: 10.1016/j.molmet.2020.101117. Epub 2020 Nov 18.
3
Uniting GDF15 and GFRAL: Therapeutic Opportunities in Obesity and Beyond.将 GDF15 和 GFRAL 联合起来:肥胖症及其它领域的治疗机会。
Trends Endocrinol Metab. 2018 Aug;29(8):560-570. doi: 10.1016/j.tem.2018.05.002. Epub 2018 Jun 1.
4
Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.长效 MIC-1/GDF15 分子治疗肥胖症:来自小鼠到猴子的证据。
Sci Transl Med. 2017 Oct 18;9(412). doi: 10.1126/scitranslmed.aan8732.
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GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss.GDF15 诱导产生令人厌恶的内脏不适状态,导致厌食和体重减轻。
Cell Rep. 2020 Apr 21;31(3):107543. doi: 10.1016/j.celrep.2020.107543.
6
Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates.活性平衡的 GLP-1/GDF15 双重激动剂可降低小鼠和非人灵长类动物的体重和代谢紊乱。
Cell Metab. 2023 Feb 7;35(2):287-298.e4. doi: 10.1016/j.cmet.2023.01.001. Epub 2023 Jan 26.
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GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.GDF15 与利拉鲁肽协同作用,但不是减肥手术诱导小鼠体重减轻所必需的。
Mol Metab. 2019 Mar;21:13-21. doi: 10.1016/j.molmet.2019.01.003. Epub 2019 Jan 14.
8
Stress-induced FGF21 and GDF15 in obesity and obesity resistance.应激诱导的成纤维细胞生长因子21和生长分化因子15在肥胖及肥胖抵抗中的作用
Trends Endocrinol Metab. 2021 Nov;32(11):904-915. doi: 10.1016/j.tem.2021.08.008. Epub 2021 Sep 13.
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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.GFRAL 是 GDF15 的受体,是配体发挥抗肥胖作用所必需的。
Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28.
10
Growth differentiation factor 15 increases following oral glucose ingestion: effect of meal composition and obesity.生长分化因子 15 在口服葡萄糖摄入后增加:膳食成分和肥胖的影响。
Eur J Endocrinol. 2016 Dec;175(6):623-631. doi: 10.1530/EJE-16-0550.

引用本文的文献

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Mammalian mitohormesis: from mitochondrial stressors to organismal benefits.哺乳动物的线粒体应激反应:从线粒体应激源到机体益处
EMBO J. 2025 Sep 8. doi: 10.1038/s44318-025-00549-3.
2
Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity.在肥胖背景下,生长分化因子15(GDF15)和成纤维细胞生长因子21(FGF21)与血糖状态及衰老的不同关联。
Geroscience. 2025 Aug 19. doi: 10.1007/s11357-025-01830-3.
3
Metabolic Messenger: growth differentiation factor 15.代谢信使:生长分化因子15
Nat Metab. 2025 Aug 18. doi: 10.1038/s42255-025-01353-3.
4
GDF15 Analogues Acting as GFRAL Ligands.作为GFRAL配体的GDF15类似物。
ChemMedChem. 2025 May 5;20(9):e202400961. doi: 10.1002/cmdc.202400961. Epub 2025 Feb 17.
5
Targeting the GDF15 Signalling for Obesity Treatment: Recent Advances and Emerging Challenges.靶向生长分化因子15信号通路治疗肥胖症:最新进展与新挑战
J Cell Mol Med. 2024 Dec;28(24):e70251. doi: 10.1111/jcmm.70251.
6
Identification and characterization of human GDF15 knockouts.鉴定和表征人 GDF15 敲除体。
Nat Metab. 2024 Oct;6(10):1913-1921. doi: 10.1038/s42255-024-01135-3. Epub 2024 Sep 26.
7
Hypothesis paper: GDF15 demonstrated promising potential in Cancer diagnosis and correlated with cardiac biomarkers.假说论文:生长分化因子15(GDF15)在癌症诊断中显示出有前景的潜力,并与心脏生物标志物相关。
Cardiooncology. 2024 Sep 4;10(1):56. doi: 10.1186/s40959-024-00263-9.
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Konjac supplementation can alleviate obesity induced by high-fat diet in mice by modulating gut microbiota and its metabolites.补充魔芋可以通过调节肠道微生物群及其代谢产物来减轻高脂饮食诱导的小鼠肥胖。
Curr Res Food Sci. 2024 Jul 14;9:100805. doi: 10.1016/j.crfs.2024.100805. eCollection 2024.
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Total and H-specific GDF-15 levels increase in caloric deprivation independently of leptin in humans.热量限制可导致总 GDF-15 和 H 特异性 GDF-15 水平升高,而与瘦素无关。
Nat Commun. 2024 Jun 18;15(1):5190. doi: 10.1038/s41467-024-49366-y.
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Obesity and the kidney: mechanistic links and therapeutic advances.肥胖与肾脏:机制关联与治疗进展。
Nat Rev Endocrinol. 2024 Jun;20(6):321-335. doi: 10.1038/s41574-024-00951-7. Epub 2024 Feb 13.