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临床应用 FAPI 成像是否正在改变实体胃肠道（或消化系统）肿瘤的 PET/CT 成像模式？

Are We Approaching a Change in Paradigm in PET/CT Imaging of Solid Gastrointestinal (or Digestive) Tract Tumors With the Clinical Application of FAPI Imaging?

机构信息

From the Department of Diagnostic Imaging (Radiology) and Nuclear Medicine, University Hospital San Pedro and Centre for Biomedical Research of La Rioja (CIBIR), Logroño, La Rioja.

Department of Pathology, University Hospital "Marqués de Valdecilla," Santander, Spain.

出版信息

Clin Nucl Med. 2023 Apr 1;48(4):318-319. doi: 10.1097/RLU.0000000000004602. Epub 2023 Feb 8.

DOI:10.1097/RLU.0000000000004602
PMID:36754356
Abstract

Studies with [ 68 Ga]Ga-labeled or [ 18 F]F-labeled fibroblast activation protein inhibitor compounds have demonstrated favorable characteristics for PET/CT imaging, making them especially interesting for digestive tumors. In this review, the recent evidence in this field and its potential clinical applications are discussed.

摘要

研究表明，[68Ga]Ga 标记或[18F]F 标记的成纤维细胞激活蛋白抑制剂化合物具有适合 PET/CT 成像的特点，因此特别适用于消化道肿瘤。本文讨论了该领域的最新证据及其潜在的临床应用。

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Are We Approaching a Change in Paradigm in PET/CT Imaging of Solid Gastrointestinal (or Digestive) Tract Tumors With the Clinical Application of FAPI Imaging?临床应用 FAPI 成像是否正在改变实体胃肠道（或消化系统）肿瘤的 PET/CT 成像模式？
Clin Nucl Med. 2023 Apr 1;48(4):318-319. doi: 10.1097/RLU.0000000000004602. Epub 2023 Feb 8.
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Clinical utility of [Ga]Ga-labeled fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography for primary staging and recurrence detection in nasopharyngeal carcinoma.镓[68Ga]标记成纤维细胞激活蛋白抑制剂（FAPI）正电子发射断层扫描/计算机断层扫描在鼻咽癌原发分期和复发检测中的临床应用。
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引用本文的文献

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Comparative diagnostic performance of [68 Ga]Ga-FAPI PET/CT and [18 F]FDGPET/CT in biliary tract cancers: a systematic review and meta-analysis.[68 Ga]镓-纤维连接蛋白激活肽正电子发射断层扫描/计算机断层扫描（PET/CT）与[18 F]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）在胆管癌中的诊断性能比较：一项系统评价和荟萃分析
Eur J Nucl Med Mol Imaging. 2025 Apr 11. doi: 10.1007/s00259-025-07264-5.
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FAPI radiopharmaceuticals in nuclear oncology and theranostics of solid tumours: are we nearer to surrounding the hallmarks of cancer?FAPI放射性药物在实体肿瘤的核肿瘤学与诊疗一体化中的应用：我们离攻克癌症的特征更近了吗？
Ann Nucl Med. 2025 May;39(5):407-423. doi: 10.1007/s12149-025-02022-x. Epub 2025 Mar 11.
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Diagnostics (Basel). 2023 Apr 27;13(9):1570. doi: 10.3390/diagnostics13091570.
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FAP expression in alpha cells of Langherhans insulae-implications for FAPI radiopharmaceuticals' use.胰岛α细胞中 FAP 的表达——对 FAPI 放射性药物应用的启示。
Eur J Nucl Med Mol Imaging. 2023 Aug;50(10):3042-3049. doi: 10.1007/s00259-023-06246-9. Epub 2023 May 4.
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Comparison of Ga-FAPI and F-FDG PET/CT for the diagnosis of primary and metastatic lesions in abdominal and pelvic malignancies: A systematic review and meta-analysis.镓标记的纤维连接蛋白激活肽（Ga-FAPI）与氟代脱氧葡萄糖（F-FDG）PET/CT在诊断腹部和盆腔恶性肿瘤原发灶及转移灶中的比较：一项系统评价与荟萃分析
Front Oncol. 2023 Feb 17;13:1093861. doi: 10.3389/fonc.2023.1093861. eCollection 2023.