Civan Caner, Isik Emine Goknur, Karadogan Seyfullah, Sanli Yasemin, Kuyumcu Serkan
From the Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Clin Nucl Med. 2023 May 1;48(5):e223-e224. doi: 10.1097/RLU.0000000000004587. Epub 2023 Feb 8.
Papillary renal cell cancer is a rare malignancy with limited treatment options in the advanced stage of the disease. We present the case of a 62-year-old man with progressive left-sided papillary renal cell carcinoma who underwent 68 Ga-FAPI (fibroblast activated protein inhibitor)-04 and 18 F-FDG PET/CT imaging. 68 Ga-FAPI-04 PET/CT demonstrated variable FAP expression in all metastatic lesions detected by 18 F-FDG PET/CT, including multiple lymph nodes, bone, and thyroid. This case highlights that FAP-targeted imaging can be a promising modality for diagnostic and theranostic use in papillary renal cell carcinoma.
乳头状肾细胞癌是一种罕见的恶性肿瘤，在疾病晚期治疗选择有限。我们报告了一例62岁男性进行性左侧乳头状肾细胞癌患者，该患者接受了68 Ga-FAPI（成纤维细胞活化蛋白抑制剂）-04和18 F-FDG PET/CT成像检查。68 Ga-FAPI-04 PET/CT显示，在18 F-FDG PET/CT检测到的所有转移病灶中，包括多个淋巴结、骨骼和甲状腺，FAP表达各不相同。该病例表明，FAP靶向成像可能是乳头状肾细胞癌诊断和诊疗应用中一种很有前景的方法。
