如何降低对曲霉菌感染的抵抗力。

How to lose resistance to Aspergillus infections.

机构信息

Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, F-35000 Rennes, France; Laboratoire de Parasitologie et Mycologie Médicale, LA-AspC Centre National de Référence des Mycoses et Antifongiques, European Excellence Center for Medical Mycology (ECMM), Centre hospitalier Universitaire de Rennes, F-35000 Rennes, France.

Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria; BioTechMed-Graz, Graz, Austria; Translational Medical Mycology Research Unit, European Confederation of Medical Mycology (ECMM) Excellence Center, Medical University of Graz, Graz, Austria.

出版信息

Trends Microbiol. 2023 Mar;31(3):222-224. doi: 10.1016/j.tim.2023.01.008. Epub 2023 Feb 6.

DOI:10.1016/j.tim.2023.01.008

PMID:36754763

Abstract

The distinct risk factors to deadly infections by Aspergillus fumigatus (Af) in intensive care unit (ICU) patients are well known; however, so far, the mechanistic link between these predisposing conditions has been unknown. Sarden et al. recently unraveled a shared B1a lymphocyte-natural antibody-neutrophil defense pathway to Af, opening new perspectives in diagnostics and therapeutics.

摘要

重症监护病房（ICU）患者感染烟曲霉（Af）导致致命感染的明确危险因素众所周知；然而，迄今为止，这些易感因素之间的机制联系尚不清楚。Sarden 等人最近揭示了 Af 存在 B1a 淋巴细胞-天然抗体-中性粒细胞防御途径，为诊断和治疗开辟了新的视角。