Murray T M, Josse R G, Heersche J N
Can Med Assoc J. 1978 Oct 21;119(8):915-20.
Hypercalcemia is a not infrequent complication of cancer that every physician should be aware of. It is a significant factor in the morbidity and mortality of cancer patients. Almost invariably hypercalcemia is associated with accelerated resorption of bone, which is thought to be mediated by humoral or metabolic factors. Three such factors, parathyroid hormone, E2 prostaglandins and osteoclast activating factor, have been strongly implicated in the pathogenesis of hypercalcemia in cancer patients. Other mechanisms for the hypercalcemia may exist. Accurate diagnosis of the disorder is important in therapy, and current research into the various mechanisms for hypercalcemia in cancer patients may well lead to new modes of therapy that are more specific and perhaps less toxic.
高钙血症是癌症患者并不罕见的并发症，每位医生都应有所了解。它是癌症患者发病和死亡的重要因素。几乎所有情况下，高钙血症都与骨吸收加速有关，这被认为是由体液或代谢因素介导的。甲状旁腺激素、E2前列腺素和破骨细胞激活因子这三种此类因素，在癌症患者高钙血症的发病机制中被强烈认为有牵连。高钙血症可能还存在其他机制。该病症的准确诊断对治疗很重要，目前对癌症患者高钙血症各种机制的研究很可能会带来更具特异性且毒性可能更低的新治疗模式。
