Muddapah Creeshen P, Weich Lize
Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
S Afr J Psychiatr. 2023 Jan 31;29:1915. doi: 10.4102/sajpsychiatry.v29i0.1915. eCollection 2023.
Alcohol use disorder (AUD) is a major public health concern in South Africa (SA). Abrupt cessation or reduction of alcohol intake in chronic users can result in withdrawal symptoms. Benzodiazepines are the treatment of choice but need to be used cautiously in patients with a lifetime history of substance abuse given their highly addictive potential. Symptom-triggered prescription of benzodiazepines during alcohol withdrawal using the Revised Clinical Institute Withdrawal for Alcohol Scale (CIWA-Ar) has been associated with improved safety and reduced benzodiazepines use.
To investigate if implementation of the CIWA-Ar during alcohol detoxification impacted the dose of benzodiazepines used and withdrawal-related outcomes.
Alcohol rehabilitation unit (ARU) at Stikland Psychiatric Hospital.
A retrospective cohort study of 135 admissions over a six-month period comparing two groups: before (2015) and after (2017) the implementation of the CIWA-Ar.
The study noted no differences in sociodemographic and alcohol-associated variables between the two groups, and there were no recorded complications in either group. The 2017 group had a lower percentage of patients that required benzodiazepines (33.8% vs. 51.4%, = 0.04) and a lower median total amount of benzodiazepines used during alcohol withdrawal (0 mg vs. 5 mg, = 0.01).
The CIWA-Ar rating scale was an effective alternative to prescribing benzodiazepines pro re nata and decreased the total dose of benzodiazepines used during alcohol withdrawal.
The use of a symptom triggered regime, like the CIWA-Ar rating scale, during withdrawal can be implemented safely in a SA treatment setting for patients with low-risk AUD.
酒精使用障碍(AUD)是南非(SA)的一个主要公共卫生问题。长期饮酒者突然戒酒或减少饮酒量会导致戒断症状。苯二氮䓬类药物是治疗的首选,但鉴于其高度成瘾性,有药物滥用史的患者需谨慎使用。使用修订后的临床研究所酒精戒断量表(CIWA-Ar)在酒精戒断期间根据症状触发开具苯二氮䓬类药物与提高安全性和减少苯二氮䓬类药物使用有关。
调查在酒精解毒过程中实施CIWA-Ar是否会影响苯二氮䓬类药物的使用剂量和与戒断相关的结果。
斯蒂克兰德精神病医院的酒精康复科(ARU)。
一项回顾性队列研究,对六个月内的135例入院患者进行比较,分为两组:CIWA-Ar实施前(2015年)和实施后(2017年)。
研究指出两组在社会人口统计学和酒精相关变量方面无差异,两组均无记录的并发症。2017年组需要苯二氮䓬类药物的患者比例较低(33.8%对51.4%,P = 0.04),酒精戒断期间使用的苯二氮䓬类药物总剂量中位数较低(0毫克对5毫克,P = 0.01)。
CIWA-Ar评定量表是按需开具苯二氮䓬类药物的有效替代方法,并减少了酒精戒断期间使用的苯二氮䓬类药物总剂量。
在南非低风险酒精使用障碍患者的治疗环境中,戒断期间使用如CIWA-Ar评定量表这样的症状触发方案可安全实施。