黄嘌呤双加氧酶在锈色环柄菇2-氮杂-8-氧代次黄嘌呤生物合成途径中的作用。
The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida.
作者信息
Kotajima Mihaya, Choi Jae-Hoon, Suzuki Tomohiro, Wu Jing, Hirai Hirofumi, Nelson David C, Ouchi Hitoshi, Inai Makoto, Dohra Hideo, Kawagishi Hirokazu
机构信息
Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, Japan.
Graduate School of Integrated Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka, Japan.
出版信息
Biosci Biotechnol Biochem. 2023 Mar 21;87(4):420-425. doi: 10.1093/bbb/zbad005.
2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-forming Lepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.
2-氮杂次黄嘌呤（AHX）和2-氮杂-8-氧代次黄嘌呤（AOH）作为蘑菇圈的致病物质被发现，已知它们在形成蘑菇圈的污白鳞伞中是内源性的。在本研究中，我们表明黄嘌呤双加氧酶，一种依赖于α-酮戊二酸的双加氧酶，可能在真菌中催化AHX向AOH的转化。此外，这种酶是首次报道的次黄嘌呤代谢中不依赖钼蝶呤的蛋白质。
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