索法酮对实验性胃炎的治疗作用。

Therapeutic effects of sofalcone on experimental gastritis.

作者信息

Kishimoto S, Okamoto K, Kambara A, Kajiyama G, Miyoshi A, Suwa T

机构信息

First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.

出版信息

Arzneimittelforschung. 1987 Aug;37(8):944-7.

PMID:3675690

Abstract

A study was made on the therapeutic effects of sofalcone (SU-88), an antiulcer agent, on erosive and atrophic gastritis induced experimentally by 6-month administration of 5 mmol/l of sodium taurocholate (TCA) in rats. A standard meal including sofalcone of 0.25% and 1.0% shortened the total length of erosions, normalized the mucosal thickness, and reduced collagenous fibers in the gastric mucosa in one month. The doses administered were 116.3 mg and 486.1 mg/kg/week for one month. Sofalcone, thus, had a good therapeutic effect on experimental erosive and atrophic gastritis in rats.

摘要

对抗溃疡药物索法酮（SU - 88）对大鼠经6个月给予5 mmol/l牛磺胆酸钠（TCA）诱导的实验性糜烂性和萎缩性胃炎的治疗效果进行了研究。含0.25%和1.0%索法酮的标准餐在1个月内缩短了糜烂的总长度，使黏膜厚度恢复正常，并减少了胃黏膜中的胶原纤维。给药剂量为116.3 mg和486.1 mg/kg/周，持续1个月。因此，索法酮对大鼠实验性糜烂性和萎缩性胃炎具有良好的治疗效果。