Kim Dong-Hee, Choi Bo-Ryoung, Jin In-Beom, Jeon Jin-Ah, Park Sang-Pil, Han Jung-Soo
Department of Biological Sciences, Konkuk University.
Behav Neurosci. 2023 Apr;137(2):95-100. doi: 10.1037/bne0000553. Epub 2023 Feb 9.
A previous study reported lateral habenula (LHb) lesions decelerated appetitive extinction. Therefore, we examined whether LHb activation accelerated appetitive extinction. In this study, rats received appetitive Pavlovian conditioning, pairing a conditioned stimulus (CS, light) with an unconditioned stimulus (food pellets), followed by CS-alone presentations. Chemogenetic LHb activation accelerated the decline in conditioned food-cup responses during extinction. The present results and the reports of previous LHb lesion studies suggest that LHb mediates appetitive extinction. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
先前的一项研究报告称，外侧缰核（LHb）损伤会减缓食欲消退。因此，我们研究了LHb激活是否会加速食欲消退。在本研究中，大鼠接受了食欲性巴甫洛夫条件反射，将条件刺激（CS，光）与非条件刺激（食物颗粒）配对，然后单独呈现CS。化学遗传学激活LHb加速了消退过程中条件性食物杯反应的下降。目前的结果以及先前LHb损伤研究的报告表明，LHb介导食欲消退。（PsycInfo数据库记录（c）2023美国心理学会，保留所有权利）
