Chaibi Ilias, Bouchatta Otmane, Bennis Mohamed, Ba-M'hamed Saadia
Laboratory of Pharmacology, Neurobiology, Anthropology and Environment, Department of Biology, Faculty of Sciences Semlalia, Cadi Ayyad University.
Behav Neurosci. 2023 Jun;137(3):155-169. doi: 10.1037/bne0000552. Epub 2023 Feb 9.
Aggression is a complex social behavior that evolved in the context of defending a territory, fighting for limited resources, and competing for mates and protection. Although aggression considered as a negative or undesirable emotion is an essential part of many species' repertoire of social behaviors. For humans, the motivations, actions, and limits of aggressive acts are not always clear. However, uncontrolled aggression may have destructive consequences, and it develops inappropriately into violence. At the neural level, several studies demonstrated that aggression is related to cortical abnormalities, including the anterior cingulate cortex (ACC). This review summarizes the state of the literature regarding the involvement of ACC in the neurobiology of aggression and impulsivity. We will first review structural and neuroanatomical studies, including volumetric and functional investigations of aggression. Next, we will discuss the neurochemical and neuropharmacological studies of aggression related to the ACC. We will focus mainly on the gamma-aminobutyric acid/glutamate balance, as well as the serotoninergic system. Finally, we will try to integrate these results and reconcile discrepancies in the field and suggest recommendations for future studies. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
攻击行为是一种复杂的社会行为，它在保卫领地、争夺有限资源以及竞争配偶和保护等背景下进化而来。尽管被视为负面或不良情绪的攻击行为是许多物种社会行为库的重要组成部分。对人类而言，攻击行为的动机、行为及限度并不总是清晰明了。然而，不受控制的攻击行为可能会产生破坏性后果，并发展为不适当的暴力行为。在神经层面，多项研究表明攻击行为与包括前扣带回皮质（ACC）在内的皮质异常有关。本综述总结了关于ACC在攻击和冲动神经生物学中作用的文献状况。我们将首先回顾结构和神经解剖学研究，包括对攻击行为的体积和功能研究。接下来，我们将讨论与ACC相关的攻击行为的神经化学和神经药理学研究。我们将主要关注γ-氨基丁酸/谷氨酸平衡以及5-羟色胺能系统。最后，我们将尝试整合这些结果，调和该领域的差异，并为未来研究提出建议。（PsycInfo数据库记录（c）2023美国心理学会，保留所有权利）
