Department of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.
Department of Chemistry, College of Science, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.
Spectrochim Acta A Mol Biomol Spectrosc. 2023 May 15;293:122444. doi: 10.1016/j.saa.2023.122444. Epub 2023 Feb 4.
Novel biomass-derived carbon dots co-doped with nitrogen and sulfur were fabricated through facile and simple synthetic method from manufactured milk powder and methionine as precursors. The as-fabricated platform was used for ratiometric fluorescence sensing of Cu (II) and bisphosphonate drug risedronate sodium. The sensing platform is based on oxidation of o-phenylenediamine by Cu (II) to form 2, 3-diaminophenazine (oxidized product) with an emission peak at 557 nm. The resultant product quenched the fluorescence emission of as-fabricated carbon dots at 470 nm through Förster resonance energy transfer (FRET) and inner-filter effect (IFE). Upon addition of risedronate sodium, the formation of 2, 3-diaminophenazine was decreased as a result of Cu (II) chelation with risedronate sodium, recovering the fluorescence emission of carbon dots. The ratio of fluorescence at 470 nm and 557 nm was measured as a function of Cu (II) and risedronate sodium concentrations. The proposed sensing platform sensitively detected Cu (II) and risedronate sodium in the range of 0.01-55 μM and 5.02-883 µM with LODs (S/N = 3) of 0.003 μM and 1.48 µM, respectively. The sensing platform exhibited a good selectivity towards Cu (II) and risedronate sodium. The sensing system was used to determine Cu (II) and risedronate sodium in different sample matrices with recoveries % in the range of 99-103 % and 97.4-103.8 %, and RSDs % in the range of 1.5-3.0 % and 1.8-3.6 %, respectively.
新型生物质衍生碳点通过简便的合成方法从奶粉和蛋氨酸作为前体制备，实现了氮和硫共掺杂。所制备的平台用于比率荧光感测 Cu（II）和双膦酸盐药物利塞膦酸钠。该传感平台基于 Cu（II）对邻苯二胺的氧化，形成发射峰在 557nm 的 2,3-二氨基吩嗪（氧化产物）。所得产物通过Förster 共振能量转移（FRET）和内滤效应（IFE）猝灭所制备的碳点在 470nm 的荧光发射。加入利塞膦酸钠后，由于 Cu（II）与利塞膦酸钠的螯合，形成 2,3-二氨基吩嗪的量减少，恢复了碳点的荧光发射。470nm 和 557nm 处的荧光比值作为 Cu（II）和利塞膦酸钠浓度的函数进行测量。该传感平台在 0.01-55μM 和 5.02-883μM 的范围内对 Cu（II）和利塞膦酸钠敏感检测，LOD（S/N=3）分别为 0.003μM 和 1.48μM。该传感平台对 Cu（II）和利塞膦酸钠具有良好的选择性。该传感系统用于测定不同样品基质中的 Cu（II）和利塞膦酸钠，回收率在 99-103%和 97.4-103.8%范围内，RSD%在 1.5-3.0%和 1.8-3.6%范围内。
