Richardson R, Riccio D C
Kent State University.
Behav Neurosci. 1987 Oct;101(5):653-7. doi: 10.1037//0735-7044.101.5.653.
Although there have been several reports that preweanling rats and mice are relatively resistant to experimentally induced retrograde amnesia, there is virtually no information concerning susceptibility to anterograde amnesia in subjects of this age. Therefore, in the present experiment, 23-day-old rats received hypothermia either prior to, or immediately after, punishment training in an attempt to induce anterograde and retrograde amnesia, respectively. When tested 24 hr later, only those subjects given hypothermia prior to training exhibited any loss of retention. Thus these results confirmed previous evidence of resistance to retrograde amnesia in preweanling rats and further demonstrated that substantial anterograde amnesia could be obtained in these subjects. Performance of subjects tested after a 5-min retention interval revealed that the poor retention performance in subjects cooled prior to training and tested 24 hr later was not due to a learning deficit. These results are also discussed with respect to the issue of the independence of anterograde and retrograde amnesia.
尽管已有多篇报道称，断奶前的大鼠和小鼠对实验诱导的逆行性遗忘相对具有抗性，但对于这个年龄段的实验对象顺行性遗忘的易感性，实际上几乎没有相关信息。因此，在本实验中，23日龄的大鼠在惩罚训练之前或之后立即接受低温处理，试图分别诱导顺行性和逆行性遗忘。在24小时后进行测试时，只有那些在训练前接受低温处理的实验对象出现了任何记忆保持的丧失。因此，这些结果证实了断奶前大鼠对逆行性遗忘具有抗性的先前证据，并进一步证明在这些实验对象中可以获得显著的顺行性遗忘。在5分钟的记忆间隔后进行测试的实验对象的表现表明，训练前接受低温处理并在24小时后进行测试的实验对象记忆保持不佳并非由于学习缺陷。还就顺行性和逆行性遗忘的独立性问题对这些结果进行了讨论。
