Winocur G
Trent University, Peterborough, Ont., Canada.
Behav Brain Res. 1990 May 7;38(2):145-54. doi: 10.1016/0166-4328(90)90012-4.
The present research was concerned with anterograde and retrograde memory for a socially transmitted food preference in rats with lesions to the dorsal hippocampus or dorsomedial thalamus, and operated controls. In Expt. 1, food-preference training was administered postoperatively and memory was tested following various delays. Both lesioned groups acquired the preference normally, but rats with hippocampal lesions displayed a rapid rate of forgetting that indicated significant anterograde amnesia. In Expt. 2, the food preference was acquired at different times preoperatively and retrograde memory was tested postoperatively. Both lesioned groups exhibited loss of memory when training immediately preceded surgery, but only rats with hippocampal lesions displayed a temporally-graded retrograde amnesia. The results confirmed the differential effects of hippocampal and thalamic lesions on memory performance. It was suggested that memory loss following thalamic lesions was related to factors associated with original learning, whereas the pattern of hippocampal amnesia reflected disruption at a later stage in the learning process.
本研究关注的是背侧海马体或背内侧丘脑损伤的大鼠以及手术对照组对一种社会传递性食物偏好的顺行性和逆行性记忆。在实验1中，术后进行食物偏好训练，并在不同延迟后测试记忆。两个损伤组都正常获得了偏好，但海马体损伤的大鼠表现出快速遗忘率，表明存在显著的顺行性遗忘。在实验2中，术前在不同时间获得食物偏好，并在术后测试逆行性记忆。当训练紧接手术前进行时，两个损伤组都表现出记忆丧失，但只有海马体损伤的大鼠表现出时间梯度性逆行性遗忘。结果证实了海马体和丘脑损伤对记忆表现的不同影响。有人提出，丘脑损伤后的记忆丧失与原始学习相关的因素有关，而海马体遗忘的模式反映了学习过程后期的破坏。
