社交焦虑障碍儿童和青少年终纹床核的异常功能连接及其年龄依赖性
Aberrant functional connectivity of the bed nucleus of the stria terminalis and its age dependence in children and adolescents with social anxiety disorder.
作者信息
Jin Shuyu, Liu Wenjing, Hu Yang, Liu Zhen, Xia Yufeng, Zhang Xiaochen, Ding Yue, Zhang Lei, Xie Shuqi, Ma Changminghao, Kang Yinzhi, Hu Zhishan, Cheng Wenhong, Yang Zhi
机构信息
Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Child and Adolescent Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Asian J Psychiatr. 2023 Apr;82:103498. doi: 10.1016/j.ajp.2023.103498. Epub 2023 Feb 1.
BACKGROUND
Social anxiety disorder (SAD) is a prevalent and impairing mental disorder among children and adolescents. The bed nucleus of the stria terminalis (BNST) plays a critical role in anxiety disorders, including valence surveillance and hypervigilance for potential threats. However, the role of BNST and its related functional network in children and adolescents with SAD has not been fully investigated. This study examined the aberration of BNST's functional connectivity and its age dependence in adolescents with SAD.
METHODS
Using a sample of 75 SAD patients and 75 healthy controls (HCs) children aged 9-18 years old, we delineated the group-by-age interaction of BNST-seeded functional connectivity (FC) during resting state and movie-watching. The relationships between BNST-seeded FC and clinical scores were also examined.
RESULTS
During movie viewing, the FC between the right BNST and the left amygdala, bilateral posterior cingulate cortex (PCC), bilateral superior temporal cortex, and right pericalcarine cortex showed a diagnostic group-by-age interaction. Compared to HCs, SAD patients showed a significant enhancement of the above FC at younger ages. Meanwhile, they showed an age-dependent decrease in FC between the right BNST and left amygdala. Furthermore, for SAD patients, FC between the right BNST and left amygdala during movie viewing was positively correlated with separation anxiety scores.
CONCLUSIONS
The right BNST plays an essential role in the aberrant brain functioning in children and adolescents with SAD. The atypicality of BNST's FC has remarkable age dependence in SAD, suggesting an association of SAD with neurodevelopmental traits.
背景
社交焦虑障碍（SAD）是儿童和青少年中一种普遍且有损害性的精神障碍。终纹床核（BNST）在焦虑障碍中起关键作用，包括对潜在威胁的效价监测和过度警觉。然而，BNST及其相关功能网络在患有SAD的儿童和青少年中的作用尚未得到充分研究。本研究调查了患有SAD的青少年中BNST功能连接的异常及其年龄依赖性。
方法
使用75名SAD患者和75名9至18岁健康对照（HCs）儿童的样本，我们描绘了静息状态和观看电影期间以BNST为种子的功能连接（FC）的组间年龄交互作用。还检查了以BNST为种子的FC与临床评分之间的关系。
结果
在观看电影期间，右侧BNST与左侧杏仁核、双侧后扣带回皮质（PCC）、双侧颞上皮质和右侧距状周皮质之间的FC显示出诊断组间年龄交互作用。与HCs相比，SAD患者在较年轻时上述FC有显著增强。同时，他们在右侧BNST与左侧杏仁核之间的FC显示出年龄依赖性下降。此外，对于SAD患者，观看电影期间右侧BNST与左侧杏仁核之间的FC与分离焦虑评分呈正相关。
结论
右侧BNST在患有SAD的儿童和青少年异常脑功能中起重要作用。BNST的FC异常在SAD中具有显著的年龄依赖性，表明SAD与神经发育特征有关。
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